ATP synthase F(1) complex subunit alpha, mitochondrial

BE0003840ProteinHumansATP5F1A

Subunit alpha, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron... It is acted on by 6 drugs in DrugBank.

Gene name
ATP5F1A
UniProtKB entry
P25705Swiss-Prot
Cellular location
Mitochondrion
Residues / weight
553 residues · 59,750 Da
Also known as
ATP synthase F1 subunit alpha · ATP5A · ATP5A1 · ATP5AL2 · ATPM

Resolves to

Protein
UniProtP25705UniProt nameATPA_HUMAN
Gene
HGNCHGNC:823NCBI Gene498GenBank28938GeneCardsATP5F1A
Pharmacology
KEGGhsa:498
Structure
PDB8H9EPDB8H9IPDB8H9L
Drugs

What you can answer from here — as of June 26, 2025

6DrugsApproved to experimental, with action, bond type and pharmacological action
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12GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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25+ReferencesStructured and connected to the statements they support
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Which approved drugs act on ATP synthase F(1) complex subunit alpha, mitochondrial, how selective are they, and which programs against it are still in active trials?

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