Beta-ketoacyl-[acyl-carrier-protein] synthase III

BE0003868ProteinEnterococcus faecalis (strain ATCC 700802 / V583)fabH

Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. It is acted on by 1 drug in DrugBank.

Gene name
fabH
UniProtKB entry
Q820T1Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
321 residues · 35,182 Da
Also known as
2.3.1.180 · 3-oxoacyl-[acyl-carrier-protein] synthase 3 · 3-oxoacyl-[acyl-carrier-protein] synthase III · Beta-ketoacyl-ACP synthase III · KAS III

Resolves to

Protein
UniProtQ820T1UniProt nameFABH_ENTFA
Gene
NCBI Gene1201733GenBank29342120
Pharmacology
KEGGefa:EF2885
Structure
PDB3IL4PDB3IL5PDB3IL6
Drugs

What you can answer from here — as of May 03, 2025

1DrugApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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2+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Beta-ketoacyl-[acyl-carrier-protein] synthase III, and which indications are they being tested in?

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