Beta-hexosaminidase

BE0003869ProteinVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)nagZ

Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides. It is acted on by 2 drugs in DrugBank.

Gene name
nagZ
UniProtKB entry
Q9KU37Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
330 residues · 36,465 Da
Also known as
3.2.1.52 · Beta-N-acetylhexosaminidase · N-acetyl-beta-glucosaminidase

Resolves to

Protein
UniProtQ9KU37UniProt nameNAGZ_VIBCH
Gene
NCBI Gene2615481GenBank9654392
Pharmacology
KEGGvch:VC0692
Structure
PDB1TR9PDB1Y65PDB2OXN
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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11GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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6+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Beta-hexosaminidase, and which indications are they being tested in?

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