Peptide deformylase 1

Details

Name
Peptide deformylase 1
Kind
protein
Synonyms
  • 3.5.1.88
  • PDF 1
  • Polypeptide deformylase 1
Gene Name
def1
UniProtKB Entry
Q819U0Swiss-Prot
Organism
Bacillus cereus (strain ATCC 14579 / DSM 31 / JCM 2152 / NBRC 15305 / NCIMB 9373 / NRRL B-3711)
NCBI Taxonomy ID
226900
Amino acid sequence
>lcl|BSEQ0017254|Peptide deformylase 1
MAVLEIIKHPNEVLETPCERVINFDKKLVKLLKDMHETMLIADGVGLAAPQVGVSLQVAV
VDVDDDTGKIELINPSILEKRGEQVGPEGCLSFPGLYGEVERADYIKVRAQNRRGKVFLL
EAEGFLARAIQHEIDHLHGVLFTSKVTRYYEENELE
Number of residues
156
Molecular Weight
17479.995
Theoretical pI
4.79
GO Classification
Functions
iron ion binding / peptide deformylase activity
Processes
translation
General Function
Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.
Specific Function
metal ion binding
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
Not Available
Cellular Location
Cytoplasmic
Gene sequence
>lcl|BSEQ0017255|Peptide deformylase 1 (def1)
ATGGCAGTTTTAGAAATAATAAAGCATCCAAATGAAGTGTTAGAAACACCATGCGAAAGA
GTAATTAACTTTGATAAAAAGTTAGTGAAATTGTTGAAAGATATGCATGAAACAATGTTA
ATTGCGGACGGAGTCGGTTTAGCTGCGCCTCAAGTAGGTGTAAGCTTGCAAGTAGCGGTT
GTTGATGTCGATGATGATACTGGGAAAATCGAGTTAATCAATCCATCAATATTAGAAAAA
CGTGGTGAACAAGTAGGTCCCGAAGGCTGTTTAAGCTTCCCGGGACTTTATGGTGAAGTA
GAACGTGCCGATTATATTAAAGTAAGAGCGCAAAATCGCCGTGGGAAAGTATTCTTATTA
GAAGCGGAAGGATTTTTAGCGCGTGCAATTCAACATGAAATTGATCATTTACACGGTGTT
TTATTTACATCGAAAGTGACAAGATATTATGAAGAAAACGAACTAGAATAG
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDQ819U0
UniProtKB Entry NameDEF1_BACCR
GenBank Protein ID29893819
GenBank Gene IDAE016877
PDB ID(s)1WS0, 1WS1
KEGG IDbce:BC3865
NCBI Gene ID1206210
General References
  1. Ivanova N, Sorokin A, Anderson I, Galleron N, Candelon B, Kapatral V, Bhattacharyya A, Reznik G, Mikhailova N, Lapidus A, Chu L, Mazur M, Goltsman E, Larsen N, D'Souza M, Walunas T, Grechkin Y, Pusch G, Haselkorn R, Fonstein M, Ehrlich SD, Overbeek R, Kyrpides N: Genome sequence of Bacillus cereus and comparative analysis with Bacillus anthracis. Nature. 2003 May 1;423(6935):87-91. [Article]

Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
2-[(Formyl-Hydroxy-Amino)-Methyl]-Heptanoic Acid [1-(2-Hydroxymethyl-Pyrrolidine-1-Carbonyl)-2-Methyl-Propyl]-AmideexperimentalunknowntargetDetails