Peptide deformylase
Details
- Name
- Peptide deformylase
- Kind
- protein
- Synonyms
- 3.5.1.88
- Polypeptide deformylase
- Gene Name
- def
- UniProtKB Entry
- Q82ZJ0Swiss-Prot
- Organism
- Enterococcus faecalis (strain ATCC 700802 / V583)
- NCBI Taxonomy ID
- 226185
- Amino acid sequence
>lcl|BSEQ0012704|Peptide deformylase MITMKDIIREGNPTLRAVAEEVPVPITEEDRQLGEDMLTFLKNSQDPVKAEELQLRGGVG LAAPQLDISKRIIAVHVPSNDPENETPSLSTVMYNPKILSHSVQDVCLGEGEGCLSVDRD VPGYVVRHNKITVSYFDMAGEKHKVRLKNYEAIVVQHEIDHINGIMFYDHINKENPFALK EGVLVIE
- Number of residues
- 187
- Molecular Weight
- 20911.76
- Theoretical pI
- 4.83
- GO Classification
- Functionsiron ion binding / peptide deformylase activityProcessestranslation
- General Function
- Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.
- Specific Function
- metal ion binding
- Pfam Domain Function
- Pep_deformylase (PF01327)
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasmic
- Gene sequence
>lcl|BSEQ0012705|Peptide deformylase (def) ATGATTACAATGAAAGATATTATTCGTGAAGGGAATCCCACACTTCGTGCTGTGGCAGAA GAAGTGCCTGTCCCTATCACTGAGGAAGACCGACAATTAGGTGAGGACATGTTGACTTTC TTAAAAAATAGTCAAGATCCAGTCAAAGCCGAAGAATTACAATTACGTGGTGGCGTTGGT TTAGCTGCACCACAATTAGATATTTCTAAACGAATTATTGCTGTCCATGTTCCTAGTAAC GACCCAGAAAACGAAACGCCTTCATTAAGTACGGTGATGTACAACCCTAAAATTTTGAGC CATTCTGTGCAAGATGTATGTTTAGGTGAAGGGGAAGGCTGTTTATCTGTCGATCGGGAT GTACCTGGGTATGTCGTTCGCCATAACAAAATTACCGTCAGTTATTTTGACATGGCTGGC GAAAAACACAAAGTTCGTTTAAAAAACTACGAAGCGATTGTGGTTCAACATGAAATTGAT CATATTAATGGCATCATGTTCTACGATCATATTAACAAAGAAAATCCATTTGCTTTAAAA GAGGGCGTTTTAGTCATCGAATAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q82ZJ0 UniProtKB Entry Name DEF_ENTFA GenBank Protein ID 29342120 GenBank Gene ID AE016830 PDB ID(s) 2OS0, 2OS1 KEGG ID efa:EF3066 NCBI Gene ID 1201912 - General References
- Paulsen IT, Banerjei L, Myers GS, Nelson KE, Seshadri R, Read TD, Fouts DE, Eisen JA, Gill SR, Heidelberg JF, Tettelin H, Dodson RJ, Umayam L, Brinkac L, Beanan M, Daugherty S, DeBoy RT, Durkin S, Kolonay J, Madupu R, Nelson W, Vamathevan J, Tran B, Upton J, Hansen T, Shetty J, Khouri H, Utterback T, Radune D, Ketchum KA, Dougherty BA, Fraser CM: Role of mobile DNA in the evolution of vancomycin-resistant Enterococcus faecalis. Science. 2003 Mar 28;299(5615):2071-4. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details 2-[(Formyl-Hydroxy-Amino)-Methyl]-Heptanoic Acid [1-(2-Hydroxymethyl-Pyrrolidine-1-Carbonyl)-2-Methyl-Propyl]-Amide experimental unknown target Details