5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase

Details

Name
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase
Kind
protein
Synonyms
  • 3.2.2.9
  • 5'-methylthioadenosine nucleosidase
  • AdoHcy nucleosidase
  • MTA nucleosidase
  • MTA/SAH nucleosidase
  • S-adenosylhomocysteine nucleosidase
  • SAH nucleosidase
  • SRH nucleosidase
Gene Name
mtnN
UniProtKB Entry
Q9KPI8Swiss-Prot
Organism
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
NCBI Taxonomy ID
243277
Amino acid sequence
>lcl|BSEQ0012713|5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase
MKIGIIGAMQQEVAILKDLIEDVQEVNQAGCTFYSGQIQGVDVVLLQSGIGKVSAALGTA
LLISQYAPDVVINTGSAGGFDASLNVGDVVISSEVRHHDADVTAFGYEIGQMAGQPAAFK
ADEKLMTVAEQALAQLPNTHAVRGLICTGDAFVCTAERQQFIRQHFPSVVAVEMEASAIA
QTCHQFKVPFVVVRAISDVADKESPLSFEEFLPLAAKSSSAMVLKMVELLK
Number of residues
231
Molecular Weight
24525.01
Theoretical pI
4.54
GO Classification
Functions
adenosylhomocysteine nucleosidase activity / methylthioadenosine nucleosidase activity
Processes
L-methionine biosynthetic process from methylthioadenosine / L-methionine biosynthetic process from S-adenosylmethionine / nucleoside catabolic process
General Function
Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively. Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine.
Specific Function
adenosylhomocysteine nucleosidase activity
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
Not Available
Cellular Location
Cytoplasmic
Gene sequence
>lcl|BSEQ0012714|5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase (mtnN)
ATGAAAATCGGCATCATCGGCGCAATGCAACAAGAAGTCGCCATCCTGAAAGATCTCATC
GAAGACGTGCAAGAAGTTAACCAAGCCGGTTGTACTTTTTACAGCGGTCAAATCCAAGGT
GTCGACGTCGTTTTACTGCAATCAGGCATTGGTAAAGTCTCGGCAGCATTAGGCACCGCT
TTGCTGATTAGCCAGTATGCGCCGGATGTGGTGATCAATACGGGTTCTGCGGGCGGCTTT
GACGCAAGTTTGAATGTGGGTGATGTGGTCATTTCAAGCGAAGTGCGCCATCACGATGCG
GATGTGACTGCATTTGGTTATGAAATTGGCCAAATGGCTGGCCAACCCGCCGCCTTTAAA
GCCGACGAGAAATTGATGACAGTGGCGGAACAAGCGCTGGCTCAATTGCCAAATACTCAT
GCGGTGCGTGGCCTTATCTGTACCGGTGATGCGTTTGTGTGCACCGCTGAACGTCAGCAA
TTTATTCGCCAACATTTCCCAAGCGTTGTTGCGGTAGAAATGGAAGCCTCTGCGATTGCG
CAAACTTGTCACCAATTCAAGGTGCCCTTTGTGGTGGTTCGCGCGATTTCTGACGTTGCT
GATAAAGAATCTCCACTGTCGTTTGAAGAGTTCTTGCCACTGGCCGCCAAAAGCTCTTCC
GCTATGGTGCTGAAAATGGTCGAACTGCTCAAATAA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDQ9KPI8
UniProtKB Entry NameMTNN_VIBCH
GenBank Protein ID9654392
GenBank Gene IDAE003852
PDB ID(s)3DP9
KEGG IDvch:VC2379
NCBI Gene ID2613048
General References
  1. Heidelberg JF, Eisen JA, Nelson WC, Clayton RA, Gwinn ML, Dodson RJ, Haft DH, Hickey EK, Peterson JD, Umayam L, Gill SR, Nelson KE, Read TD, Tettelin H, Richardson D, Ermolaeva MD, Vamathevan J, Bass S, Qin H, Dragoi I, Sellers P, McDonald L, Utterback T, Fleishmann RD, Nierman WC, White O, Salzberg SL, Smith HO, Colwell RR, Mekalanos JJ, Venter JC, Fraser CM: DNA sequence of both chromosomes of the cholera pathogen Vibrio cholerae. Nature. 2000 Aug 3;406(6795):477-83. [Article]

Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
(3R,4S)-1-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-[(butylsulfanyl)methyl]pyrrolidin-3-olexperimentalunknowntargetDetails