5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase

BE0003891ProteinVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)mtnN

Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively. It is acted on by 1 drug in DrugBank.

Gene name
mtnN
UniProtKB entry
Q9KPI8Swiss-Prot
Cellular location
Cytoplasmic
Residues / weight
231 residues · 24,525 Da
Also known as
3.2.2.9 · 5'-deoxyadenosine nucleosidase · 5'-methylthioadenosine nucleosidase · AdoHcy nucleosidase · dAdo nucleosidase

Resolves to

Protein
UniProtQ9KPI8UniProt nameMTNN_VIBCH
Gene
NCBI Gene2613048GenBank9654392
Pharmacology
KEGGvch:VC2379
Structure
PDB3DP9
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
Sign in
5GO termsFunction, process and component, as structured annotations
Sign in
1Pfam domainDomain architecture mapped to Pfam families and clans
Sign in
2+ReferencesStructured and connected to the statements they support
Sign in

Which compounds in development act on 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, and which indications are they being tested in?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In