5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase
Details
- Name
- 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase
- Kind
- protein
- Synonyms
- 3.2.2.9
- 5'-methylthioadenosine nucleosidase
- AdoHcy nucleosidase
- MTA nucleosidase
- MTA/SAH nucleosidase
- S-adenosylhomocysteine nucleosidase
- SAH nucleosidase
- SRH nucleosidase
- Gene Name
- mtnN
- UniProtKB Entry
- Q9KPI8Swiss-Prot
- Organism
- Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
- NCBI Taxonomy ID
- 243277
- Amino acid sequence
>lcl|BSEQ0012713|5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase MKIGIIGAMQQEVAILKDLIEDVQEVNQAGCTFYSGQIQGVDVVLLQSGIGKVSAALGTA LLISQYAPDVVINTGSAGGFDASLNVGDVVISSEVRHHDADVTAFGYEIGQMAGQPAAFK ADEKLMTVAEQALAQLPNTHAVRGLICTGDAFVCTAERQQFIRQHFPSVVAVEMEASAIA QTCHQFKVPFVVVRAISDVADKESPLSFEEFLPLAAKSSSAMVLKMVELLK
- Number of residues
- 231
- Molecular Weight
- 24525.01
- Theoretical pI
- 4.54
- GO Classification
- Functionsadenosylhomocysteine nucleosidase activity / methylthioadenosine nucleosidase activityProcessesL-methionine biosynthetic process from methylthioadenosine / L-methionine biosynthetic process from S-adenosylmethionine / nucleoside catabolic process
- General Function
- Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively. Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine.
- Specific Function
- adenosylhomocysteine nucleosidase activity
- Pfam Domain Function
- PNP_UDP_1 (PF01048)
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasmic
- Gene sequence
>lcl|BSEQ0012714|5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase (mtnN) ATGAAAATCGGCATCATCGGCGCAATGCAACAAGAAGTCGCCATCCTGAAAGATCTCATC GAAGACGTGCAAGAAGTTAACCAAGCCGGTTGTACTTTTTACAGCGGTCAAATCCAAGGT GTCGACGTCGTTTTACTGCAATCAGGCATTGGTAAAGTCTCGGCAGCATTAGGCACCGCT TTGCTGATTAGCCAGTATGCGCCGGATGTGGTGATCAATACGGGTTCTGCGGGCGGCTTT GACGCAAGTTTGAATGTGGGTGATGTGGTCATTTCAAGCGAAGTGCGCCATCACGATGCG GATGTGACTGCATTTGGTTATGAAATTGGCCAAATGGCTGGCCAACCCGCCGCCTTTAAA GCCGACGAGAAATTGATGACAGTGGCGGAACAAGCGCTGGCTCAATTGCCAAATACTCAT GCGGTGCGTGGCCTTATCTGTACCGGTGATGCGTTTGTGTGCACCGCTGAACGTCAGCAA TTTATTCGCCAACATTTCCCAAGCGTTGTTGCGGTAGAAATGGAAGCCTCTGCGATTGCG CAAACTTGTCACCAATTCAAGGTGCCCTTTGTGGTGGTTCGCGCGATTTCTGACGTTGCT GATAAAGAATCTCCACTGTCGTTTGAAGAGTTCTTGCCACTGGCCGCCAAAAGCTCTTCC GCTATGGTGCTGAAAATGGTCGAACTGCTCAAATAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q9KPI8 UniProtKB Entry Name MTNN_VIBCH GenBank Protein ID 9654392 GenBank Gene ID AE003852 PDB ID(s) 3DP9 KEGG ID vch:VC2379 NCBI Gene ID 2613048 - General References
- Heidelberg JF, Eisen JA, Nelson WC, Clayton RA, Gwinn ML, Dodson RJ, Haft DH, Hickey EK, Peterson JD, Umayam L, Gill SR, Nelson KE, Read TD, Tettelin H, Richardson D, Ermolaeva MD, Vamathevan J, Bass S, Qin H, Dragoi I, Sellers P, McDonald L, Utterback T, Fleishmann RD, Nierman WC, White O, Salzberg SL, Smith HO, Colwell RR, Mekalanos JJ, Venter JC, Fraser CM: DNA sequence of both chromosomes of the cholera pathogen Vibrio cholerae. Nature. 2000 Aug 3;406(6795):477-83. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details (3R,4S)-1-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-[(butylsulfanyl)methyl]pyrrolidin-3-ol experimental unknown target Details