Cytochrome c oxidase subunit 2

Details

Name
Cytochrome c oxidase subunit 2
Kind
protein
Synonyms
  • 1.9.3.1
  • ctaC
  • Cytochrome c ba(3) subunit II
  • Cytochrome c oxidase polypeptide II
  • Cytochrome cba3 subunit 2
Gene Name
cbaB
UniProtKB Entry
Q5SJ80Swiss-Prot
Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
NCBI Taxonomy ID
300852
Amino acid sequence
>lcl|BSEQ0019491|Cytochrome c oxidase subunit 2
MVDEHKAHKAILAYEKGWLAFSLAMLFVFIALIAYTLATHTAGVIPAGKLERVDPTTVRQ
EGPWADPAQAVVQTGPNQYTVYVLAFAFGYQPNPIEVPQGAEIVFKITSPDVIHGFHVEG
TNINVEVLPGEVSTVRYTFKRPGEYRIICNQYCGLGHQNMFGTIVVKE
Number of residues
168
Molecular Weight
18563.305
Theoretical pI
6.51
GO Classification
Functions
copper ion binding / cytochrome-c oxidase activity
Processes
electron transport chain
Components
integral component of membrane / plasma membrane / respiratory chain
General Function
Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).
Specific Function
copper ion binding
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
4-38
Cellular Location
Cell membrane
Gene sequence
>lcl|BSEQ0019492|Cytochrome c oxidase subunit 2 (cbaB)
ATGGTGGACGAGCACAAGGCCCACAAGGCGATCCTGGCCTACGAGAAGGGGTGGCTCGCC
TTCTCCTTGGCGATGCTCTTCGTCTTCATCGCCCTCATCGCCTACACCCTGGCCACCCAC
ACCGCCGGGGTCATTCCCGCCGGAAAGCTTGAGCGCGTGGACCCCACCACGGTAAGGCAG
GAAGGCCCCTGGGCCGACCCGGCCCAAGCGGTGGTGCAGACCGGCCCCAACCAGTACACG
GTCTACGTCCTGGCCTTCGCCTTCGGCTACCAGCCGAACCCCATTGAGGTGCCCCAAGGG
GCGGAGATCGTCTTCAAGATCACGAGCCCGGACGTGATCCACGGCTTTCACGTGGAGGGC
ACCAACATCAACGTGGAGGTGCTCCCGGGCGAGGTCTCCACCGTGCGCTACACCTTCAAA
AGGCCCGGGGAGTACCGCATCATCTGCAACCAGTACTGCGGCCTAGGCCACCAGAACATG
TTCGGCACGATCGTGGTGAAGGAGTGA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDQ5SJ80
UniProtKB Entry NameCOX2_THET8
GenBank Protein ID5053134
GenBank Gene IDL09121
PDB ID(s)1EHK, 2QPD, 2QPE, 3BVD, 3EH3, 3EH4, 3EH5, 3QJQ, 3QJR, 3QJS, 3QJT, 3QJU, 3QJV, 3S33, 3S38, 3S39, 3S3A, 3S3B, 3S3C, 3S3D, 3S8F, 3S8G, 4FA7, 4FAA, 4G70, 4G71, 4G72, 4G7Q, 4G7R, 4G7S, 4GP4, 4GP5, 4GP8, 4N4Y
KEGG IDttj:TTHA1134
NCBI Gene ID3169672
General References
  1. Keightley JA, Zimmermann BH, Mather MW, Springer P, Pastuszyn A, Lawrence DM, Fee JA: Molecular genetic and protein chemical characterization of the cytochrome ba3 from Thermus thermophilus HB8. J Biol Chem. 1995 Sep 1;270(35):20345-58. [Article]
  2. Soulimane T, Buse G, Bourenkov GP, Bartunik HD, Huber R, Than ME: Structure and mechanism of the aberrant ba(3)-cytochrome c oxidase from thermus thermophilus. EMBO J. 2000 Apr 17;19(8):1766-76. [Article]

Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
B-nonylglucosideexperimentalunknowntargetDetails