Epoxide hydrolase
Details
- Name
- Epoxide hydrolase
- Kind
- protein
- Synonyms
- SubName: PROBABLE EPOXIDE HYDROLASE EPHB (EPOXIDE HYDRATASE)
- Gene Name
- Not Available
- UniProtKB Entry
- P95276TrEMBL
- Organism
- Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
- NCBI Taxonomy ID
- 83331
- Amino acid sequence
>lcl|BSEQ0022092|Epoxide hydrolase MSQVHRILNCRGTRIHAVADSPPDQQGPLVVLLHGFPESWYSWRHQIPALAGAGYRVVAI DQRGYGRSSKYRVQKAYRIKELVGDVVGVLDSYGAEQAFVVGHDWGAPVAWTFAWLHPDR CAGVVGISVPFAGRGVIGLPGSPFGERRPSDYHLELAGPGRVWYQDYFAVQDGIITEIEE DLRGWLLGLTYTVSGEGMMAATKAAVDAGVDLESMDPIDVIRAGPLCMAEGARLKDAFVY PETMPAWFTEADLDFYTGEFERSGFGGPLSFYHNIDNDWHDLADQQGKPLTPPALFIGGQ YDVGTIWGAQAIERAHEVMPNYRGTHMIADVGHWIQQEAPEETNRLLLDFLGGLRP
- Number of residues
- 356
- Molecular Weight
- 39297.085
- Theoretical pI
- 4.88
- GO Classification
- Functionsepoxide hydrolase B activity / protein homodimerization activity
- General Function
- Could be involved in detoxification of extraneous host-cell epoxides. Catalyzes the hydrolysis of small aromatic epoxide-containing substrates such as trans-1,3-diphenylpropene oxide, trans and cis-stilbene oxide, and terpenoid epoxide.
- Specific Function
- epoxide hydrolase B activity
- Pfam Domain Function
- Abhydrolase_1 (PF00561)
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0022093|Epoxide hydrolase GTGTCGCAGGTCCATCGAATCCTGAACTGCCGGGGCACCCGCATCCATGCCGTGGCGGAC AGCCCACCCGACCAACAGGGACCGTTGGTGGTGTTGCTGCACGGGTTTCCGGAGTCCTGG TACTCGTGGCGGCATCAGATTCCCGCGCTTGCCGGCGCGGGCTACCGCGTGGTGGCCATC GACCAGCGCGGGTATGGCCGCTCGTCGAAATACCGGGTGCAAAAGGCCTACCGCATCAAG GAATTGGTTGGCGACGTCGTGGGCGTCCTCGACTCCTATGGTGCGGAGCAGGCTTTCGTG GTGGGCCACGACTGGGGTGCGCCGGTCGCCTGGACCTTCGCCTGGCTGCACCCCGACCGA TGCGCCGGCGTGGTGGGAATCAGCGTTCCGTTTGCCGGTCGCGGCGTGATCGGCCTGCCG GGCAGCCCGTTCGGCGAGCGCCGTCCCAGCGACTACCACCTGGAGCTGGCCGGGCCCGGA AGGGTCTGGTATCAGGACTATTTCGCCGTGCAGGACGGCATCATCACCGAGATCGAGGAA GACTTGCGGGGCTGGCTGCTCGGGTTGACCTACACCGTTTCCGGTGAGGGGATGATGGCG GCGACCAAGGCGGCCGTCGACGCGGGCGTCGACCTGGAGTCCATGGACCCGATCGACGTG ATCCGTGCCGGACCGCTGTGTATGGCCGAAGGCGCGCGGCTCAAGGACGCGTTCGTCTAC CCGGAGACCATGCCGGCCTGGTTCACCGAGGCCGATCTCGATTTCTACACTGGCGAATTC GAACGTTCCGGGTTCGGCGGGCCGCTGAGCTTCTACCACAACATCGACAACGACTGGCAC GACCTGGCCGACCAGCAAGGCAAGCCGCTCACCCCGCCGGCTCTGTTCATCGGCGGCCAG TATGACGTCGGCACCATCTGGGGCGCGCAGGCCATCGAGCGTGCGCACGAAGTCATGCCG AACTACCGCGGCACCCACATGATCGCCGACGTCGGACACTGGATCCAGCAGGAAGCGCCC GAAGAGACCAACCGGCTGTTGCTCGACTTCCTAGGCGGGCTGCGGCCGTGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P95276 UniProtKB Entry Name P95276_MYCTO GenBank Protein ID 13879042 GenBank Gene ID AE000516 PDB ID(s) 2ZJF KEGG ID mtc:MT1988 - General References
- Fleischmann RD, Alland D, Eisen JA, Carpenter L, White O, Peterson J, DeBoy R, Dodson R, Gwinn M, Haft D, Hickey E, Kolonay JF, Nelson WC, Umayam LA, Ermolaeva M, Salzberg SL, Delcher A, Utterback T, Weidman J, Khouri H, Gill J, Mikula A, Bishai W, Jacobs Jr WR Jr, Venter JC, Fraser CM: Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains. J Bacteriol. 2002 Oct;184(19):5479-90. [Article]
- Biswal BK, Morisseau C, Garen G, Cherney MM, Garen C, Niu C, Hammock BD, James MN: The molecular structure of epoxide hydrolase B from Mycobacterium tuberculosis and its complex with a urea-based inhibitor. J Mol Biol. 2008 Sep 12;381(4):897-912. doi: 10.1016/j.jmb.2008.06.030. Epub 2008 Jun 17. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details 1,3-diphenylurea experimental unknown target Details