2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase

BE0003969ProteinBurkholderia xenovorans (strain LB400)bphD

Catalyzes an unusual C-C bond hydrolysis of 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid (HOPDA) to produce benzoic acid and 2-hydroxy-2,4-pentadienoic acid (HPD). It is acted on by 4 drugs in DrugBank.

Gene name
bphD
UniProtKB entry
P47229Swiss-Prot
Residues / weight
286 residues · 32,029 Da
Also known as
2,6-dioxo-6-phenylhexa-3-enoate hydrolase · 3.7.1.8 · HOPDA hydrolase

Resolves to

Protein
UniProtP47229UniProt nameBPHD_PARXL
Gene
NCBI Gene4010698GenBank397886
Pharmacology
KEGGbxb:DR64_8619
Structure
PDB2OG1PDB2PU5PDB2PU7
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
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3GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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9+ReferencesStructured and connected to the statements they support
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Which compounds in development act on 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase, and which indications are they being tested in?

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