Protocatechuate 3,4-dioxygenase beta chain
Details
- Name
- Protocatechuate 3,4-dioxygenase beta chain
- Kind
- protein
- Synonyms
- 1.13.11.3
- 3,4-PCD
- Gene Name
- pcaH
- UniProtKB Entry
- P00437Swiss-Prot
- Organism
- Pseudomonas putida
- NCBI Taxonomy ID
- 303
- Amino acid sequence
>lcl|BSEQ0012811|Protocatechuate 3,4-dioxygenase beta chain MPAQDNSRFVIRDRNWHPKALTPDYKTSIARSPRQALVSIPQSISETTGPNFSHLGFGAH DHDLLLNFNNGGLPIGERIIVAGRVVDQYGKPVPNTLVEMWQANAGGRYRHKNDRYLAPL DPNFGGVGRCLTDSDGYYSFRTIKPGPYPWRNGPNDWRPAHIHFGISGPSIATKLITQLY FEGDPLIPMCPIVKSIANPEAVQQLIAKLDMNNANPMDCLAYRFDIVLRGQRKTHFENC
- Number of residues
- 239
- Molecular Weight
- 26793.25
- Theoretical pI
- 9.12
- GO Classification
- Functionsferric iron binding / protocatechuate 3,4-dioxygenase activityProcesses3,4-dihydroxybenzoate catabolic process / beta-ketoadipate pathway
- General Function
- Plays an essential role in the utilization of numerous aromatic and hydroaromatic compounds via the beta-ketoadipate pathway.
- Specific Function
- ferric iron binding
- Pfam Domain Function
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0007713|720 bp ATGCCCGCCCAGGACAACAGCCGCTTCGTGATCCGTGATCGCAACTGGCACCCCAAAGCC CTTACGCCTGACTACAAAACGTCCATTGCCCGCTCGCCGCGCCAGGCACTGGTCAGCATT CCACAGTCGATCAGCGAAACCACTGGTCCGAACTTTTCCCACCTGGGCTTCGGCGCCCAC GACCATGACCTGCTGCTGAACTTCAACAACGGTGGCCTGCCAATCGGCGAGCGCATCATC GTGGCCGGCCGCGTCGTCGACCAGTACGGCAAGCCTGTGCCGAACACCCTGGTGGAGATG TGGCAAGCCAACGCCGGTGGCCGCTACCGGCACAAGAACGACCGTTACCTGGCACCGCTG GACCCGAACTTTGGTGGTGTCGGCCGTTGCCTGACCGACAGCGACGGCTACTACAGCTTC CGCACCATCAAGCCGGGCCCGTACCCCTGGCGCAACGGCCCGAACGACTGGCGCCCGGCG CACATCCACTTCGGCATCAGCGGCCCGTCGATTGCGACCAAGCTGATCACCCAGTTGTAT TTCGAGGGTGACCCGCTGATCCCGATGTGCCCGATCGTCAAGTCGATCGCCAACCCTGAA GCTGTACAGCAGTTGATCGCCAAGCTCGACATGAACAACGCCAACCCGATGGACTGCCTG GCCTACCGCTTTGACATCGTGCTGCGCGGCCAGCGCAAGACCCACTTCGAAAACTGCTGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P00437 UniProtKB Entry Name PCXB_PSEPU GenBank Protein ID 294344 GenBank Gene ID L14836 PDB ID(s) 1YKK, 1YKL, 1YKM, 1YKN, 1YKO, 1YKP, 2PCD, 3LKT, 3LMX, 3LXV, 3MFL, 3MI1, 3MI5, 3MV4, 3MV6, 3PCA, 3PCB, 3PCC, 3PCD, 3PCE, 3PCF, 3PCG, 3PCH, 3PCI, 3PCJ, 3PCK, 3PCL, 3PCM, 3PCN, 3T63, 3T67, 4WHO, 4WHP, 4WHQ, 4WHR, 4WHS - General References
- Frazee RW, Livingston DM, LaPorte DC, Lipscomb JD: Cloning, sequencing, and expression of the Pseudomonas putida protocatechuate 3,4-dioxygenase genes. J Bacteriol. 1993 Oct;175(19):6194-202. [Article]
- Iwaki M, Kagamiyama H, Nozaki M: The complete amino acid sequence of the beta-subunit of protocatechuate 3,4-dioxygenase from Pseudomonas aeruginosa. J Biochem. 1979 Oct;86(4):1159-62. [Article]
- Ohlendorf DH, Lipscomb JD, Weber PC: Structure and assembly of protocatechuate 3,4-dioxygenase. Nature. 1988 Nov 24;336(6197):403-5. [Article]
- Ohlendorf DH, Orville AM, Lipscomb JD: Structure of protocatechuate 3,4-dioxygenase from Pseudomonas aeruginosa at 2.15 A resolution. J Mol Biol. 1994 Dec 16;244(5):586-608. [Article]
- Orville AM, Elango N, Lipscomb JD, Ohlendorf DH: Structures of competitive inhibitor complexes of protocatechuate 3,4-dioxygenase: multiple exogenous ligand binding orientations within the active site. Biochemistry. 1997 Aug 19;36(33):10039-51. [Article]
- Orville AM, Lipscomb JD, Ohlendorf DH: Crystal structures of substrate and substrate analog complexes of protocatechuate 3,4-dioxygenase: endogenous Fe3+ ligand displacement in response to substrate binding. Biochemistry. 1997 Aug 19;36(33):10052-66. [Article]
- Elgren TE, Orville AM, Kelly KA, Lipscomb JD, Ohlendorf DH, Que L Jr: Crystal structure and resonance Raman studies of protocatechuate 3,4-dioxygenase complexed with 3,4-dihydroxyphenylacetate. Biochemistry. 1997 Sep 23;36(38):11504-13. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details 2-(3,4-Dihydroxyphenyl)Acetic Acid experimental unknown target Details