Pikromycin polyketide synthase component PikAIV

BE0004058ProteinStreptomyces venezuelaepikAIV

Involved in the biosynthesis of 12- and 14-membered ring macrolactone antibiotics such as methymycin and neomethymycin, and pikromycin and narbomycin, respectively. It is acted on by 3 drugs in DrugBank.

Gene name
pikAIV
UniProtKB entry
Q9ZGI2TrEMBL
Cellular location
Cytoplasmic
Residues / weight
1,346 residues · 141,913 Da
Also known as
2.3.1.239 · Narbonolide/10-deoxymethynolide synthase PikA4, module 6 · Narbonolide/10-deoxymethynolide synthase PikAIV · Pikromycin PKS component PikAIV · PKS

Resolves to

Protein
UniProtQ9ZGI2UniProt namePIKA4_STRVZ
Gene
GenBank3800832
Structure
PDB1MN6PDB1MNAPDB1MNQ
Drugs

What you can answer from here — as of May 03, 2025

3DrugsApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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6Pfam domainsDomain architecture mapped to Pfam families and clans
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8+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Pikromycin polyketide synthase component PikAIV, and which indications are they being tested in?

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