Prolyl tripeptidyl peptidase

Details

Name
Prolyl tripeptidyl peptidase
Kind
protein
Synonyms
  • 3.4.14.12
  • Prolyl tripeptidyl peptidase 81.8 kDa form
  • Prolyl tripeptidyl peptidase A
  • PTP
Gene Name
ptpA
UniProtKB Entry
Q7MUW6Swiss-Prot
Organism
Porphyromonas gingivalis (strain ATCC BAA-308 / W83)
NCBI Taxonomy ID
242619
Amino acid sequence
>lcl|BSEQ0012852|Prolyl tripeptidyl peptidase
MKKTIFQQLFLSVCALTVALPCSAQSPETSGKEFTLEQLMPGGKEFYNFYPEYVVGLQWM
GDNYVFIEGDDLVFNKANGKSAQTTRFSAADLNALMPEGCKFQTTDAFPSFRTLDAGRGL
VVLFTQGGLVGFDMLARKVTYLFDTNEETASLDFSPVGDRVAYVRNHNLYIARGGKLGEG
MSRAIAVTIDGTETLVYGQAVHQREFGIEKGTFWSPKGSCLAFYRMDQSMVKPTPIVDYH
PLEAESKPLYYPMAGTPSHHVTVGIYHLATGKTVYLQTGEPKEKFLTNLSWSPDENILYV
AEVNRAQNECKVNAYDAETGRFVRTLFVETDKHYVEPLHPLTFLPGSNNQFIWQSRRDGW
NHLYLYDTTGRLIRQVTKGEWEVTNFAGFDPKGTRLYFESTEASPLERHFYCIDIKGGKT
KDLTPESGMHRTQLSPDGSAIIDIFQSPTVPRKVTVTNIGKGSHTLLEAKNPDTGYAMPE
IRTGTIMAADGQTPLYYKLTMPLHFDPAKKYPVIVYVYGGPHAQLVTKTWRSSVGGWDIY
MAQKGYAVFTVDSRGSANRGAAFEQVIHRRLGQTEMADQMCGVDFLKSQSWVDADRIGVH
GWSYGGFMTTNLMLTHGDVFKVGVAGGPVIDWNRYEIMYGERYFDAPQENPEGYDAANLL
KRAGDLKGRLMLIHGAIDPVVVWQHSLLFLDACVKARTYPDYYVYPSHEHNVMGPDRVHL
YETITRYFTDHL
Number of residues
732
Molecular Weight
82265.855
Theoretical pI
6.62
GO Classification
Functions
aminopeptidase activity / serine-type peptidase activity
General Function
Serine proteinase. Releases tripeptides from the free amino terminus of proteins. Has a requirement for Pro in the P1 position, but is inactivated by Pro in the P1' position.
Specific Function
aminopeptidase activity
Pfam Domain Function
Signal Regions
1-24
Transmembrane Regions
Not Available
Cellular Location
Cytoplasmic
Gene sequence
>lcl|BSEQ0012853|Prolyl tripeptidyl peptidase (ptpA)
ATGAAGAAGACAATCTTCCAACAACTATTTCTGTCTGTTTGTGCCCTTACAGTGGCCTTG
CCTTGTTCGGCTCAGTCTCCTGAAACGAGTGGTAAGGAGTTTACTCTTGAGCAACTGATG
CCCGGAGGAAAAGAGTTTTATAACTTTTACCCCGAATACGTGGTCGGTTTGCAATGGATG
GGAGACAATTATGTCTTTATCGAGGGTGATGATTTAGTTTTTAATAAGGCGAATGGCAAA
TCGGCTCAGACGACCAGATTTTCTGCTGCCGATCTCAATGCACTCATGCCGGAGGGATGC
AAATTTCAGACGACTGATGCTTTCCCTTCATTCCGCACACTCGATGCCGGACGGGGACTG
GTCGTTCTATTTACCCAAGGAGGATTAGTCGGATTCGATATGCTTGCTCGAAAGGTGACT
TATCTTTTCGATACCAATGAGGAGACGGCTTCTTTGGATTTTTCTCCTGTGGGAGACCGT
GTTGCCTATGTCAGAAACCATAACCTTTACATTGCTCGTGGAGGTAAATTGGGAGAAGGT
ATGTCACGAGCTATCGCTGTGACTATCGATGGAACTGAGACTCTCGTATATGGCCAGGCC
GTACACCAGCGTGAATTCGGTATCGAAAAAGGTACATTCTGGTCTCCAAAAGGGAGCTGC
CTTGCTTTCTATCGAATGGATCAGAGTATGGTGAAGCCTACCCCGATAGTGGATTATCAT
CCGCTCGAAGCCGAGTCCAAACCGCTTTATTACCCCATGGCAGGTACTCCGTCACACCAC
GTTACGGTTGGGATCTATCATCTGGCCACAGGTAAGACCGTCTATCTACAAACGGGTGAA
CCCAAGGAAAAATTTCTGACGAATTTGAGTTGGAGTCCGGACGAAAATATCTTGTATGTA
GCTGAGGTGAATCGTGCTCAAAACGAATGTAAGGTAAATGCCTATGACGCTGAGACCGGT
AGATTCGTCCGTACGCTTTTTGTTGAAACCGATAAACATTATGTAGAGCCGTTACATCCC
CTGACATTCCTTCCGGGAAGTAACAATCAGTTCATTTGGCAGAGCCGTCGCGACGGATGG
AACCATCTCTATCTGTATGATACTACAGGTCGTCTGATCCGTCAGGTGACAAAAGGGGAG
TGGGAGGTTACAAACTTTGCAGGCTTCGATCCCAAGGGAACACGGCTCTATTTCGAAAGT
ACCGAAGCCAGCCCTCTCGAACGCCATTTTTACTGTATTGATATCAAAGGAGGAAAGACA
AAAGATCTGACTCCGGAGTCGGGAATGCACCGCACTCAGCTATCTCCTGATGGTTCTGCC
ATAATCGATATTTTTCAGTCACCTACTGTCCCGCGTAAGGTTACAGTGACAAATATCGGC
AAAGGGTCTCACACACTCTTGGAGGCTAAGAACCCCGATACGGGCTATGCCATGCCGGAG
ATCAGAACGGGTACCATCATGGCGGCCGATGGGCAGACACCTCTTTATTACAAGCTCACG
ATGCCGCTTCATTTCGATCCGGCAAAGAAATATCCTGTTATTGTCTATGTTTACGGAGGA
CCTCATGCCCAACTCGTAACCAAGACATGGCGCAGCTCTGTCGGTGGATGGGATATCTAT
ATGGCACAGAAAGGCTATGCCGTCTTTACGGTGGATAGTCGCGGATCTGCCAATAGAGGG
GCTGCTTTCGAGCAGGTTATTCATCGTCGTTTGGGGCAGACCGAGATGGCCGATCAGATG
TGCGGTGTGGATTTCCTCAAGAGCCAATCATGGGTGGATGCCGATAGAATAGGAGTACAT
GGCTGGAGCTATGGTGGCTTTATGACTACGAATCTGATGCTTACGCACGGCGATGTCTTC
AAAGTCGGAGTAGCCGGCGGGCCTGTCATAGACTGGAATCGATATGAGATTATGTACGGT
GAGCGTTATTTCGATGCGCCACAGGAAAATCCCGAAGGATACGATGCTGCCAACCTGCTC
AAACGAGCCGGTGATCTGAAAGGACGACTTATGCTGATTCATGGAGCGATCGATCCGGTC
GTGGTATGGCAGCATTCACTCCTTTTCCTTGATGCTTGCGTGAAGGCACGCACCTATCCT
GACTATTACGTCTATCCGAGCCACGAACATAATGTGATGGGGCCGGACAGAGTACATTTG
TATGAAACAATAACCCGTTATTTCACAGATCACTTATGA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDQ7MUW6
UniProtKB Entry NamePTP_PORGI
GenBank Protein ID34396192
GenBank Gene IDAE015924
PDB ID(s)2D5L, 2DCM, 2EEP, 2Z3W, 2Z3Z
KEGG IDpgi:PG1361
NCBI Gene ID2551645
General References
  1. Nelson KE, Fleischmann RD, DeBoy RT, Paulsen IT, Fouts DE, Eisen JA, Daugherty SC, Dodson RJ, Durkin AS, Gwinn M, Haft DH, Kolonay JF, Nelson WC, Mason T, Tallon L, Gray J, Granger D, Tettelin H, Dong H, Galvin JL, Duncan MJ, Dewhirst FE, Fraser CM: Complete genome sequence of the oral pathogenic Bacterium porphyromonas gingivalis strain W83. J Bacteriol. 2003 Sep;185(18):5591-601. [Article]
  2. Banbula A, Mak P, Bugno M, Silberring J, Dubin A, Nelson D, Travis J, Potempa J: Prolyl tripeptidyl peptidase from Porphyromonas gingivalis. A novel enzyme with possible pathological implications for the development of periodontitis. J Biol Chem. 1999 Apr 2;274(14):9246-52. [Article]
  3. Ito K, Nakajima Y, Xu Y, Yamada N, Onohara Y, Ito T, Matsubara F, Kabashima T, Nakayama K, Yoshimoto T: Crystal structure and mechanism of tripeptidyl activity of prolyl tripeptidyl aminopeptidase from Porphyromonas gingivalis. J Mol Biol. 2006 Sep 15;362(2):228-40. Epub 2006 Aug 17. [Article]
  4. Xu Y, Nakajima Y, Ito K, Zheng H, Oyama H, Heiser U, Hoffmann T, Gartner UT, Demuth HU, Yoshimoto T: Novel inhibitor for prolyl tripeptidyl aminopeptidase from Porphyromonas gingivalis and details of substrate-recognition mechanism. J Mol Biol. 2008 Jan 18;375(3):708-19. Epub 2007 Oct 3. [Article]

Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
GLYCYLALANYL-N-2-NAPHTHYL-L-PROLINEAMIDEexperimentalunknowntargetDetails