Prolyl tripeptidyl peptidase
Details
- Name
- Prolyl tripeptidyl peptidase
- Kind
- protein
- Synonyms
- 3.4.14.12
- Prolyl tripeptidyl peptidase 81.8 kDa form
- Prolyl tripeptidyl peptidase A
- PTP
- Gene Name
- ptpA
- UniProtKB Entry
- Q7MUW6Swiss-Prot
- Organism
- Porphyromonas gingivalis (strain ATCC BAA-308 / W83)
- NCBI Taxonomy ID
- 242619
- Amino acid sequence
>lcl|BSEQ0012852|Prolyl tripeptidyl peptidase MKKTIFQQLFLSVCALTVALPCSAQSPETSGKEFTLEQLMPGGKEFYNFYPEYVVGLQWM GDNYVFIEGDDLVFNKANGKSAQTTRFSAADLNALMPEGCKFQTTDAFPSFRTLDAGRGL VVLFTQGGLVGFDMLARKVTYLFDTNEETASLDFSPVGDRVAYVRNHNLYIARGGKLGEG MSRAIAVTIDGTETLVYGQAVHQREFGIEKGTFWSPKGSCLAFYRMDQSMVKPTPIVDYH PLEAESKPLYYPMAGTPSHHVTVGIYHLATGKTVYLQTGEPKEKFLTNLSWSPDENILYV AEVNRAQNECKVNAYDAETGRFVRTLFVETDKHYVEPLHPLTFLPGSNNQFIWQSRRDGW NHLYLYDTTGRLIRQVTKGEWEVTNFAGFDPKGTRLYFESTEASPLERHFYCIDIKGGKT KDLTPESGMHRTQLSPDGSAIIDIFQSPTVPRKVTVTNIGKGSHTLLEAKNPDTGYAMPE IRTGTIMAADGQTPLYYKLTMPLHFDPAKKYPVIVYVYGGPHAQLVTKTWRSSVGGWDIY MAQKGYAVFTVDSRGSANRGAAFEQVIHRRLGQTEMADQMCGVDFLKSQSWVDADRIGVH GWSYGGFMTTNLMLTHGDVFKVGVAGGPVIDWNRYEIMYGERYFDAPQENPEGYDAANLL KRAGDLKGRLMLIHGAIDPVVVWQHSLLFLDACVKARTYPDYYVYPSHEHNVMGPDRVHL YETITRYFTDHL
- Number of residues
- 732
- Molecular Weight
- 82265.855
- Theoretical pI
- 6.62
- GO Classification
- Functionsaminopeptidase activity / serine-type peptidase activity
- General Function
- Serine proteinase. Releases tripeptides from the free amino terminus of proteins. Has a requirement for Pro in the P1 position, but is inactivated by Pro in the P1' position.
- Specific Function
- aminopeptidase activity
- Pfam Domain Function
- Signal Regions
- 1-24
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasmic
- Gene sequence
>lcl|BSEQ0012853|Prolyl tripeptidyl peptidase (ptpA) ATGAAGAAGACAATCTTCCAACAACTATTTCTGTCTGTTTGTGCCCTTACAGTGGCCTTG CCTTGTTCGGCTCAGTCTCCTGAAACGAGTGGTAAGGAGTTTACTCTTGAGCAACTGATG CCCGGAGGAAAAGAGTTTTATAACTTTTACCCCGAATACGTGGTCGGTTTGCAATGGATG GGAGACAATTATGTCTTTATCGAGGGTGATGATTTAGTTTTTAATAAGGCGAATGGCAAA TCGGCTCAGACGACCAGATTTTCTGCTGCCGATCTCAATGCACTCATGCCGGAGGGATGC AAATTTCAGACGACTGATGCTTTCCCTTCATTCCGCACACTCGATGCCGGACGGGGACTG GTCGTTCTATTTACCCAAGGAGGATTAGTCGGATTCGATATGCTTGCTCGAAAGGTGACT TATCTTTTCGATACCAATGAGGAGACGGCTTCTTTGGATTTTTCTCCTGTGGGAGACCGT GTTGCCTATGTCAGAAACCATAACCTTTACATTGCTCGTGGAGGTAAATTGGGAGAAGGT ATGTCACGAGCTATCGCTGTGACTATCGATGGAACTGAGACTCTCGTATATGGCCAGGCC GTACACCAGCGTGAATTCGGTATCGAAAAAGGTACATTCTGGTCTCCAAAAGGGAGCTGC CTTGCTTTCTATCGAATGGATCAGAGTATGGTGAAGCCTACCCCGATAGTGGATTATCAT CCGCTCGAAGCCGAGTCCAAACCGCTTTATTACCCCATGGCAGGTACTCCGTCACACCAC GTTACGGTTGGGATCTATCATCTGGCCACAGGTAAGACCGTCTATCTACAAACGGGTGAA CCCAAGGAAAAATTTCTGACGAATTTGAGTTGGAGTCCGGACGAAAATATCTTGTATGTA GCTGAGGTGAATCGTGCTCAAAACGAATGTAAGGTAAATGCCTATGACGCTGAGACCGGT AGATTCGTCCGTACGCTTTTTGTTGAAACCGATAAACATTATGTAGAGCCGTTACATCCC CTGACATTCCTTCCGGGAAGTAACAATCAGTTCATTTGGCAGAGCCGTCGCGACGGATGG AACCATCTCTATCTGTATGATACTACAGGTCGTCTGATCCGTCAGGTGACAAAAGGGGAG TGGGAGGTTACAAACTTTGCAGGCTTCGATCCCAAGGGAACACGGCTCTATTTCGAAAGT ACCGAAGCCAGCCCTCTCGAACGCCATTTTTACTGTATTGATATCAAAGGAGGAAAGACA AAAGATCTGACTCCGGAGTCGGGAATGCACCGCACTCAGCTATCTCCTGATGGTTCTGCC ATAATCGATATTTTTCAGTCACCTACTGTCCCGCGTAAGGTTACAGTGACAAATATCGGC AAAGGGTCTCACACACTCTTGGAGGCTAAGAACCCCGATACGGGCTATGCCATGCCGGAG ATCAGAACGGGTACCATCATGGCGGCCGATGGGCAGACACCTCTTTATTACAAGCTCACG ATGCCGCTTCATTTCGATCCGGCAAAGAAATATCCTGTTATTGTCTATGTTTACGGAGGA CCTCATGCCCAACTCGTAACCAAGACATGGCGCAGCTCTGTCGGTGGATGGGATATCTAT ATGGCACAGAAAGGCTATGCCGTCTTTACGGTGGATAGTCGCGGATCTGCCAATAGAGGG GCTGCTTTCGAGCAGGTTATTCATCGTCGTTTGGGGCAGACCGAGATGGCCGATCAGATG TGCGGTGTGGATTTCCTCAAGAGCCAATCATGGGTGGATGCCGATAGAATAGGAGTACAT GGCTGGAGCTATGGTGGCTTTATGACTACGAATCTGATGCTTACGCACGGCGATGTCTTC AAAGTCGGAGTAGCCGGCGGGCCTGTCATAGACTGGAATCGATATGAGATTATGTACGGT GAGCGTTATTTCGATGCGCCACAGGAAAATCCCGAAGGATACGATGCTGCCAACCTGCTC AAACGAGCCGGTGATCTGAAAGGACGACTTATGCTGATTCATGGAGCGATCGATCCGGTC GTGGTATGGCAGCATTCACTCCTTTTCCTTGATGCTTGCGTGAAGGCACGCACCTATCCT GACTATTACGTCTATCCGAGCCACGAACATAATGTGATGGGGCCGGACAGAGTACATTTG TATGAAACAATAACCCGTTATTTCACAGATCACTTATGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q7MUW6 UniProtKB Entry Name PTP_PORGI GenBank Protein ID 34396192 GenBank Gene ID AE015924 PDB ID(s) 2D5L, 2DCM, 2EEP, 2Z3W, 2Z3Z KEGG ID pgi:PG1361 NCBI Gene ID 2551645 - General References
- Nelson KE, Fleischmann RD, DeBoy RT, Paulsen IT, Fouts DE, Eisen JA, Daugherty SC, Dodson RJ, Durkin AS, Gwinn M, Haft DH, Kolonay JF, Nelson WC, Mason T, Tallon L, Gray J, Granger D, Tettelin H, Dong H, Galvin JL, Duncan MJ, Dewhirst FE, Fraser CM: Complete genome sequence of the oral pathogenic Bacterium porphyromonas gingivalis strain W83. J Bacteriol. 2003 Sep;185(18):5591-601. [Article]
- Banbula A, Mak P, Bugno M, Silberring J, Dubin A, Nelson D, Travis J, Potempa J: Prolyl tripeptidyl peptidase from Porphyromonas gingivalis. A novel enzyme with possible pathological implications for the development of periodontitis. J Biol Chem. 1999 Apr 2;274(14):9246-52. [Article]
- Ito K, Nakajima Y, Xu Y, Yamada N, Onohara Y, Ito T, Matsubara F, Kabashima T, Nakayama K, Yoshimoto T: Crystal structure and mechanism of tripeptidyl activity of prolyl tripeptidyl aminopeptidase from Porphyromonas gingivalis. J Mol Biol. 2006 Sep 15;362(2):228-40. Epub 2006 Aug 17. [Article]
- Xu Y, Nakajima Y, Ito K, Zheng H, Oyama H, Heiser U, Hoffmann T, Gartner UT, Demuth HU, Yoshimoto T: Novel inhibitor for prolyl tripeptidyl aminopeptidase from Porphyromonas gingivalis and details of substrate-recognition mechanism. J Mol Biol. 2008 Jan 18;375(3):708-19. Epub 2007 Oct 3. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details GLYCYLALANYL-N-2-NAPHTHYL-L-PROLINEAMIDE experimental unknown target Details