D-amino-acid oxidase

BE0004141ProteinHumansDAO

Catalyzes the oxidative deamination of D-amino acids with broad substrate specificity (PubMed:16616139, PubMed:17088322, PubMed:17303072, PubMed:18544534, PubMed:20368421, PubMed:20567862, PubMed:20603179, PubMed:22203986, PubMed:23219954, PubMed:23391306, PubMed:25030849, PubMed:25701391, PubMed:29274788, PubMed:29326945, PubMed:30938755, PubMed:31799256, PubMed:32730563, PubMed:33484270, PubMed:34041270, PubMed:37558109, PubMed:38035964). It is acted on by 13 drugs in DrugBank.

Gene name
DAO
UniProtKB entry
P14920Swiss-Prot
Cellular location
Peroxisome matrix
Residues / weight
347 residues · 39,474 Da
Also known as
1.4.3.3 · DAAO · DAMOX · DAO

Resolves to

Protein
UniProtP14920UniProt nameOXDA_HUMAN
Gene
HGNCHGNC:2671NCBI Gene1610GenBank30446GeneCardsDAO
Pharmacology
KEGGhsa:1610
Structure
PDB2DU8PDB2E48PDB2E49
Drugs

What you can answer from here — as of September 07, 2019

13DrugsApproved to experimental, with action, bond type and pharmacological action
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8GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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26+ReferencesStructured and connected to the statements they support
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Which approved drugs act on D-amino-acid oxidase, how selective are they, and which programs against it are still in active trials?

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