Myelin P2 protein

Details

Name
Myelin P2 protein
Kind
protein
Synonyms
  • Peripheral myelin protein 2
Gene Name
PMP2
UniProtKB Entry
P02689Swiss-Prot
Organism
Humans
NCBI Taxonomy ID
9606
Amino acid sequence
>lcl|BSEQ0012902|Myelin P2 protein
MSNKFLGTWKLVSSENFDDYMKALGVGLATRKLGNLAKPTVIISKKGDIITIRTESTFKN
TEISFKLGQEFEETTADNRKTKSIVTLQRGSLNQVQRWDGKETTIKRKLVNGKMVAECKM
KGVVCTRIYEKV
Number of residues
132
Molecular Weight
14909.305
Theoretical pI
10.55
GO Classification
Processes
fatty acid transport
Components
cytosol / nucleus
General Function
May play a role in lipid transport protein in Schwann cells. May bind cholesterol
Specific Function
Cholesterol binding
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Gene sequence
>lcl|BSEQ0012903|Myelin P2 protein (PMP2)
ATGAGCAACAAATTCCTGGGCACCTGGAAACTTGTCTCTAGTGAGAACTTTGACGATTAC
ATGAAAGCTCTGGGTGTGGGGTTAGCCACCAGAAAACTGGGAAATTTGGCCAAACCCACT
GTGATCATCAGCAAGAAAGGAGATATTATAACTATACGAACTGAAAGTACCTTTAAAAAT
ACAGAAATCTCCTTCAAGCTAGGCCAGGAATTTGAAGAAACCACAGCTGACAATAGAAAG
ACCAAGAGCATCGTAACCCTGCAGAGAGGATCACTGAATCAAGTGCAGAGATGGGATGGC
AAAGAGACAACCATAAAGAGAAAGCTAGTGAATGGGAAAATGGTAGCGGAATGTAAAATG
AAGGGCGTGGTGTGCACCAGAATCTATGAGAAGGTCTGA
Chromosome Location
8
Locus
8q21.13
External Identifiers
ResourceLink
UniProtKB IDP02689
UniProtKB Entry NameMYP2_HUMAN
GenBank Protein ID35186
GenBank Gene IDX62167
GeneCard IDPMP2
HGNC IDHGNC:9117
PDB ID(s)2WUT, 3NR3, 4A1H, 4A1Y, 4A8Z, 4BVM, 4D6A, 4D6B, 5N4M, 5N4P, 5N4Q, 6EW2, 6EW4, 6EW5, 6S2M, 6S2S, 6STS, 6XU5, 6XU9, 6XUA, 6XUW, 6XVQ, 6XVR, 6XVS, 6XVY, 6XW9, 7NRW, 7NSR, 7NTP, 7O60
KEGG IDhsa:5375
NCBI Gene ID5375
General References
  1. Hayasaka K, Nanao K, Tahara M, Sato W, Takada G, Miura M, Uyemura K: Isolation and sequence determination of cDNA encoding P2 protein of human peripheral myelin. Biochem Biophys Res Commun. 1991 Nov 27;181(1):204-7. [Article]
  2. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [Article]
  3. Nusbaum C, Mikkelsen TS, Zody MC, Asakawa S, Taudien S, Garber M, Kodira CD, Schueler MG, Shimizu A, Whittaker CA, Chang JL, Cuomo CA, Dewar K, FitzGerald MG, Yang X, Allen NR, Anderson S, Asakawa T, Blechschmidt K, Bloom T, Borowsky ML, Butler J, Cook A, Corum B, DeArellano K, DeCaprio D, Dooley KT, Dorris L 3rd, Engels R, Glockner G, Hafez N, Hagopian DS, Hall JL, Ishikawa SK, Jaffe DB, Kamat A, Kudoh J, Lehmann R, Lokitsang T, Macdonald P, Major JE, Matthews CD, Mauceli E, Menzel U, Mihalev AH, Minoshima S, Murayama Y, Naylor JW, Nicol R, Nguyen C, O'Leary SB, O'Neill K, Parker SC, Polley A, Raymond CK, Reichwald K, Rodriguez J, Sasaki T, Schilhabel M, Siddiqui R, Smith CL, Sneddon TP, Talamas JA, Tenzin P, Topham K, Venkataraman V, Wen G, Yamazaki S, Young SK, Zeng Q, Zimmer AR, Rosenthal A, Birren BW, Platzer M, Shimizu N, Lander ES: DNA sequence and analysis of human chromosome 8. Nature. 2006 Jan 19;439(7074):331-5. [Article]
  4. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
  5. Narayanan V, Ripepi B, Jabs EW, Hawkins A, Griffin C, Tennekoon G: Partial structure and mapping of the human myelin P2 protein gene. J Neurochem. 1994 Dec;63(6):2010-3. [Article]
  6. Suzuki M, Kitamura K, Sakamoto Y, Uyemura K: The complete amino acid sequence of human P2 protein. J Neurochem. 1982 Dec;39(6):1759-62. [Article]
  7. Majava V, Polverini E, Mazzini A, Nanekar R, Knoll W, Peters J, Natali F, Baumgartel P, Kursula I, Kursula P: Structural and functional characterization of human peripheral nervous system myelin protein P2. PLoS One. 2010 Apr 22;5(4):e10300. doi: 10.1371/journal.pone.0010300. [Article]

Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
S-HydroxycysteineexperimentalunknowntargetDetails
Palmitic AcidapprovedunknowntargetDetails
Oleic Acidapproved, investigational, vet_approvedunknowntargetDetails
Dodecyldimethylamine N-oxideexperimentalunknowntargetDetails