Identification
- Summary
Palmitic Acid is a fatty used as a food additive and emollient or surfactant in cosmetics.
- Generic Name
- Palmitic Acid
- DrugBank Accession Number
- DB03796
- Background
A common saturated fatty acid found in fats and waxes including olive oil, palm oil, and body lipids.
- Type
- Small Molecule
- Groups
- Approved
- Structure
Structure for Palmitic Acid (DB03796)
- Weight
- Average: 256.4241
Monoisotopic: 256.240230268 - Chemical Formula
- C16H32O2
- Synonyms
- 1-hexyldecanoic acid
- 1-Pentadecanecarboxylic acid
- Hexadecanoate
- Hexadecanoic acid
- Hexadecoic acid
- Hexadecylic acid
- Hexaectylic acid
- Palmitate
- Palmitic Acid
- Palmitinic acid
- Palmitinsäure
- External IDs
- EDENOR C 16-98-100
- FEMA NO. 2832
- HYDROFOL ACID 1690
- IMEX C 1498
- KORTACID 1698
- LOXIOL EP 278
- NSC-5030
Pharmacology
- Indication
Not Available
Reduce drug development failure ratesBuild, train, & validate machine-learning modelswith evidence-based and structured datasets.Build, train, & validate predictive machine-learning models with structured datasets.- Associated Conditions
- Contraindications & Blackbox Warnings
Prevent Adverse Drug Events TodayTap into our Clinical API for life-saving information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events with our Clinical API- Pharmacodynamics
Palmitic acid is the first fatty acid produced during lipogenesis (fatty acid synthesis) and from which longer fatty acids can be produced. Palmitate negatively feeds back on acetyl-CoA carboxylase (ACC) which is responsible for converting acetyl-ACP to malonyl-ACP on the growing acyl chain, thus preventing further palmitate generation
- Mechanism of action
Target Actions Organism UAlpha-lactalbumin Not Available Humans UPeroxisome proliferator-activated receptor alpha Not Available Humans URhodopsin Not Available Humans UPalmitoyl-protein thioesterase 1 Not Available Humans UMyelin P2 protein Not Available Humans UGlycodelin Not Available Humans UHepatocyte nuclear factor 4-gamma Not Available Humans ULipid binding protein Not Available Geobacillus stearothermophilus UCytochrome P450 2C8 Not Available Humans UTrafficking protein particle complex subunit 3 Not Available Humans UFatty acid-binding protein TM_1468 Not Available Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099) - Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Acute oral toxicity (LD50) in rat is >10000 mg/kg
- Pathways
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- No interactions found.
Products
Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.- Product Ingredients
Ingredient UNII CAS InChI Key 16-chloropalmitic acid Not Available Not Available Not applicable - Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image Borage Oil Capsules Palmitic Acid (96 mg) + Gamolenic acid (258 mg) + Linoleic acid (375 mg) + Oleic Acid (148 mg) Capsule Oral General Nutrition Canada Inc. 2001-10-15 2009-08-05 Canada 
Flaxseed Oil Capsules Palmitic Acid (54 mg) + Linoleic acid (144 mg) + Oleic Acid (165 mg) + alpha-Linolenic acid (594 mg) Capsule Oral General Nutrition Canada Inc. 1998-05-27 2007-08-01 Canada Huile D'onagre Vitamin E Palmitic Acid (7 %) + Linoleic acid (72 %) + Oleic Acid (9 %) + Stearic acid (1 %) + Vitamin E (15 %) + alpha-Linolenic acid (11 %) Capsule Oral Le Naturiste J.M.B. Inc. 1987-12-31 2000-08-23 Canada Jayjun Anti Dust Fresh Foam Cleanser Palmitic Acid (11.16 g/90mL) + Lauric acid (6.30 g/90mL) + Stearic acid (6.84 g/90mL) Liquid Topical Jayjun Cosmetic Co.,ltd. 2018-12-01 2019-11-01 US 
Jayjun New Real Water Brightening Black Mask Step 01 Real Water Shining Vita Cleansing Foa M Palmitic Acid (0.16 g/1.5mL) + Lauric acid (0.04 g/1.5mL) + Stearic acid (0.06 g/1.5mL) Liquid Topical Jayjun Cosmetic Co.,ltd. 2018-12-01 2019-11-01 US Jayjun Real Water Brightening Black Mask Step 01 Real Water Cleansing Foa M Palmitic Acid (0.25 g/1.5mL) + Lauric acid (0.06 g/1.5mL) + Myristic acid (0.06 g/1.5mL) + Stearic acid (0.07 g/1.5mL) Liquid Topical Jayjun Cosmetic Co.,ltd. 2018-12-01 2019-11-01 US Jayjun Real Water Shining Cleansing Foa M Palmitic Acid (22.35 g/150mL) + Lauric acid (5.25 g/150mL) + Stearic acid (11.40 g/150mL) Injectable Foam Topical Jayjun Cosmetic Co.,ltd. 2018-12-01 2019-11-01 US Jayjun Real Water Shining Vita Cleansing Foa M Palmitic Acid (16.50 g/150mL) + Lauric acid (4.50 g/150mL) + Myristic acid (4.50 g/150mL) + Stearic acid (6.45 g/150mL) Injectable Foam Topical Jayjun Cosmetic Co.,ltd. 2018-12-01 2019-11-01 US Levovist - Pws IV (4g Granules /vial) Palmitic Acid (1 mg / g) + Galactose (999 mg / g) Powder, for solution Intravenous Berlex Laboratories, Inc. 1997-12-19 2003-06-26 Canada Sha-lem Palmitic Acid (7.25 g/30mL) + Bismuth subcarbonate (1.89 g/30mL) + Boric acid (0.95 g/30mL) + Oleic Acid (14.5 g/30mL) + Stearic acid (7.25 g/30mL) Ointment Topical Shalem Products, Inc. 1992-05-08 Not applicable US - Unapproved/Other Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image Jayjun Anti Dust Fresh Foam Cleanser Palmitic Acid (11.16 g/90mL) + Lauric acid (6.30 g/90mL) + Stearic acid (6.84 g/90mL) Liquid Topical Jayjun Cosmetic Co.,ltd. 2018-12-01 2019-11-01 US Jayjun New Real Water Brightening Black Mask Step 01 Real Water Shining Vita Cleansing Foa M Palmitic Acid (0.16 g/1.5mL) + Lauric acid (0.04 g/1.5mL) + Stearic acid (0.06 g/1.5mL) Liquid Topical Jayjun Cosmetic Co.,ltd. 2018-12-01 2019-11-01 US Jayjun Real Water Brightening Black Mask Step 01 Real Water Cleansing Foa M Palmitic Acid (0.25 g/1.5mL) + Lauric acid (0.06 g/1.5mL) + Myristic acid (0.06 g/1.5mL) + Stearic acid (0.07 g/1.5mL) Liquid Topical Jayjun Cosmetic Co.,ltd. 2018-12-01 2019-11-01 US Jayjun Real Water Shining Cleansing Foa M Palmitic Acid (22.35 g/150mL) + Lauric acid (5.25 g/150mL) + Stearic acid (11.40 g/150mL) Injectable Foam Topical Jayjun Cosmetic Co.,ltd. 2018-12-01 2019-11-01 US Jayjun Real Water Shining Vita Cleansing Foa M Palmitic Acid (16.50 g/150mL) + Lauric acid (4.50 g/150mL) + Myristic acid (4.50 g/150mL) + Stearic acid (6.45 g/150mL) Injectable Foam Topical Jayjun Cosmetic Co.,ltd. 2018-12-01 2019-11-01 US Sha-lem Palmitic Acid (7.25 g/30mL) + Bismuth subcarbonate (1.89 g/30mL) + Boric acid (0.95 g/30mL) + Oleic Acid (14.5 g/30mL) + Stearic acid (7.25 g/30mL) Ointment Topical Shalem Products, Inc. 1992-05-08 Not applicable US
Categories
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as long-chain fatty acids. These are fatty acids with an aliphatic tail that contains between 13 and 21 carbon atoms.
- Kingdom
- Organic compounds
- Super Class
- Lipids and lipid-like molecules
- Class
- Fatty Acyls
- Sub Class
- Fatty acids and conjugates
- Direct Parent
- Long-chain fatty acids
- Alternative Parents
- Straight chain fatty acids / Monocarboxylic acids and derivatives / Carboxylic acids / Organic oxides / Hydrocarbon derivatives / Carbonyl compounds
- Substituents
- Aliphatic acyclic compound / Carbonyl group / Carboxylic acid / Carboxylic acid derivative / Hydrocarbon derivative / Long-chain fatty acid / Monocarboxylic acid or derivatives / Organic oxide / Organic oxygen compound / Organooxygen compound
- Molecular Framework
- Aliphatic acyclic compounds
- External Descriptors
- long-chain fatty acid, straight-chain saturated fatty acid (CHEBI:15756) / Straight chain fatty acids, Saturated fatty acids (C00249) / Straight chain fatty acids (LMFA01010001)
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- 2V16EO95H1
- CAS number
- 57-10-3
- InChI Key
- IPCSVZSSVZVIGE-UHFFFAOYSA-N
- InChI
- InChI=1S/C16H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h2-15H2,1H3,(H,17,18)
- IUPAC Name
- hexadecanoic acid
- SMILES
- CCCCCCCCCCCCCCCC(O)=O
References
- Synthesis Reference
Walter R. Fehr, Earl G. Hammond, "Elevated palmitic acid production in soybeans." U.S. Patent US5750846, issued February, 1997.
US5750846- General References
- Not Available
- External Links
- Human Metabolome Database
- HMDB0000220
- KEGG Drug
- D05341
- KEGG Compound
- C00249
- PubChem Compound
- 985
- PubChem Substance
- 46506400
- ChemSpider
- 960
- BindingDB
- 50152850
- 1370621
- ChEBI
- 15756
- ChEMBL
- CHEMBL82293
- ZINC
- ZINC000006072466
- Guide to Pharmacology
- GtP Drug Page
- PDBe Ligand
- PLM
- Wikipedia
- Palmitic_acid
- PDB Entries
- 1aca / 1b0o / 1b56 / 1be2 / 1cov / 1e12 / 1e7h / 1eh5 / 1ev1 / 1gxa … show 577 more
- MSDS
- Download (73 KB)
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 2 Completed Diagnostic Coronary Artery Disease (CAD) 1 2 Completed Treatment Hypoxemic Acute Respiratory Failure 1 2 Terminated Prevention Chronic Lung Disease of Prematurity / Premature Births / Respiratory Distress Syndrome, Newborn 1 0 Completed Basic Science Fatty Liver 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Capsule Oral Liquid Topical Injectable foam Topical Powder, for solution Intravenous Ointment Topical Suspension Endotracheal - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Solid
- Experimental Properties
Property Value Source melting point (°C) 61.8 °C PhysProp boiling point (°C) 351.5 °C PhysProp water solubility 0.04 mg/L (at 25 °C) ROBB.ID (1966) logP 7.17 SANGSTER (1993) logS -6.81 ADME Research, USCD - Predicted Properties
Property Value Source Water Solubility 0.000407 mg/mL ALOGPS logP 7.23 ALOGPS logP 6.26 Chemaxon logS -5.8 ALOGPS pKa (Strongest Acidic) 4.95 Chemaxon Physiological Charge -1 Chemaxon Hydrogen Acceptor Count 2 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 37.3 Å2 Chemaxon Rotatable Bond Count 14 Chemaxon Refractivity 77.08 m3·mol-1 Chemaxon Polarizability 34.36 Å3 Chemaxon Number of Rings 0 Chemaxon Bioavailability 0 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
Property Value Probability Human Intestinal Absorption + 0.9888 Blood Brain Barrier + 0.9488 Caco-2 permeable + 0.8326 P-glycoprotein substrate Non-substrate 0.6321 P-glycoprotein inhibitor I Non-inhibitor 0.9598 P-glycoprotein inhibitor II Non-inhibitor 0.9277 Renal organic cation transporter Non-inhibitor 0.9266 CYP450 2C9 substrate Non-substrate 0.7886 CYP450 2D6 substrate Non-substrate 0.8956 CYP450 3A4 substrate Non-substrate 0.6982 CYP450 1A2 substrate Inhibitor 0.8326 CYP450 2C9 inhibitor Non-inhibitor 0.8808 CYP450 2D6 inhibitor Non-inhibitor 0.9554 CYP450 2C19 inhibitor Non-inhibitor 0.9578 CYP450 3A4 inhibitor Non-inhibitor 0.9484 CYP450 inhibitory promiscuity Low CYP Inhibitory Promiscuity 0.9647 Ames test Non AMES toxic 0.9865 Carcinogenicity Non-carcinogens 0.6452 Biodegradation Ready biodegradable 0.8795 Rat acute toxicity 1.3275 LD50, mol/kg Not applicable hERG inhibition (predictor I) Weak inhibitor 0.9322 hERG inhibition (predictor II) Non-inhibitor 0.8868
Spectra
- Mass Spec (NIST)
- Download (10.5 KB)
- Spectra
Targets
Build, predict & validate machine-learning models
Use our structured and evidence-based datasets to unlock newinsights and accelerate drug research.
Use our structured and evidence-based datasets to unlock new insights and accelerate drug research.
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Lactose synthase activity
- Specific Function
- Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to ...
- Gene Name
- LALBA
- Uniprot ID
- P00709
- Uniprot Name
- Alpha-lactalbumin
- Molecular Weight
- 16224.695 Da
References
- Barbana C, Perez MD, Pocovi C, Sanchez L, Wehbi Z: Interaction of human alpha-lactalbumin with fatty acids: determination of binding parameters. Biochemistry (Mosc). 2008 Jun;73(6):711-6. [Article]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Zinc ion binding
- Specific Function
- Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleyleth...
- Gene Name
- PPARA
- Uniprot ID
- Q07869
- Uniprot Name
- Peroxisome proliferator-activated receptor alpha
- Molecular Weight
- 52224.595 Da
References
- Murakami K, Ide T, Suzuki M, Mochizuki T, Kadowaki T: Evidence for direct binding of fatty acids and eicosanoids to human peroxisome proliferators-activated receptor alpha. Biochem Biophys Res Commun. 1999 Jul 14;260(3):609-13. [Article]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Photoreceptor activity
- Specific Function
- Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a ...
- Gene Name
- RHO
- Uniprot ID
- P08100
- Uniprot Name
- Rhodopsin
- Molecular Weight
- 38892.335 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [Article]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [Article]
- Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [Article]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Palmitoyl-coa hydrolase activity
- Specific Function
- Removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides during lysosomal degradation. Prefers acyl chain lengths of 14 to 18 carbons.
- Gene Name
- PPT1
- Uniprot ID
- P50897
- Uniprot Name
- Palmitoyl-protein thioesterase 1
- Molecular Weight
- 34193.245 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [Article]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [Article]
- Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [Article]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Transporter activity
- Specific Function
- May play a role in lipid transport protein in Schwann cells. May bind cholesterol.
- Gene Name
- PMP2
- Uniprot ID
- P02689
- Uniprot Name
- Myelin P2 protein
- Molecular Weight
- 14909.305 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [Article]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [Article]
- Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [Article]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Small molecule binding
- Specific Function
- This protein is, quantitatively, the main protein synthesized and secreted in the endometrium from mid-luteal phase of the menstrual cycle and during the first semester of pregnancy.
- Gene Name
- PAEP
- Uniprot ID
- P09466
- Uniprot Name
- Glycodelin
- Molecular Weight
- 20624.015 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [Article]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [Article]
- Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [Article]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Zinc ion binding
- Specific Function
- Transcription factor. Has a lower transcription activation potential than HNF4-alpha.
- Gene Name
- HNF4G
- Uniprot ID
- Q14541
- Uniprot Name
- Hepatocyte nuclear factor 4-gamma
- Molecular Weight
- 45876.235 Da
- Kind
- Protein
- Organism
- Geobacillus stearothermophilus
- Pharmacological action
- Unknown
- General Function
- Lipid binding
- Specific Function
- Not Available
- Gene Name
- Not Available
- Uniprot ID
- P83812
- Uniprot Name
- Lipid binding protein
- Molecular Weight
- 32173.81 Da
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Steroid hydroxylase activity
- Specific Function
- Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
- Gene Name
- CYP2C8
- Uniprot ID
- P10632
- Uniprot Name
- Cytochrome P450 2C8
- Molecular Weight
- 55824.275 Da
References
- Schoch GA, Yano JK, Wester MR, Griffin KJ, Stout CD, Johnson EF: Structure of human microsomal cytochrome P450 2C8. Evidence for a peripheral fatty acid binding site. J Biol Chem. 2004 Mar 5;279(10):9497-503. Epub 2003 Dec 15. [Article]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Not Available
- Specific Function
- May play a role in vesicular transport from endoplasmic reticulum to Golgi.
- Gene Name
- TRAPPC3
- Uniprot ID
- O43617
- Uniprot Name
- Trafficking protein particle complex subunit 3
- Molecular Weight
- 20273.915 Da
- Kind
- Protein
- Organism
- Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
- Pharmacological action
- Unknown
- General Function
- Lipid binding
- Specific Function
- Binds long-chain fatty acids, such as palmitate, and may play a role in lipid transport or fatty acid metabolism.
- Gene Name
- Not Available
- Uniprot ID
- Q9X1H9
- Uniprot Name
- Fatty acid-binding protein TM_1468
- Molecular Weight
- 32574.335 Da
Carriers
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Toxic substance binding
- Specific Function
- Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloid...
- Gene Name
- ALB
- Uniprot ID
- P02768
- Uniprot Name
- Serum albumin
- Molecular Weight
- 69365.94 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [Article]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [Article]
- Simard JR, Zunszain PA, Hamilton JA, Curry S: Location of high and low affinity fatty acid binding sites on human serum albumin revealed by NMR drug-competition analysis. J Mol Biol. 2006 Aug 11;361(2):336-51. Epub 2006 Jun 30. [Article]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Transporter activity
- Specific Function
- Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus (By similarity).
- Gene Name
- FABP4
- Uniprot ID
- P15090
- Uniprot Name
- Fatty acid-binding protein, adipocyte
- Molecular Weight
- 14718.815 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [Article]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [Article]
- Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [Article]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Transporter activity
- Specific Function
- High specificity for fatty acids. Highest affinity for C18 chain length. Decreasing the chain length or introducing double bonds reduces the affinity. May be involved in keratinocyte differentiation.
- Gene Name
- FABP5
- Uniprot ID
- Q01469
- Uniprot Name
- Fatty acid-binding protein, epidermal
- Molecular Weight
- 15164.36 Da
References
- Zimmerman AW, van Moerkerk HT, Veerkamp JH: Ligand specificity and conformational stability of human fatty acid-binding proteins. Int J Biochem Cell Biol. 2001 Sep;33(9):865-76. doi: 10.1016/s1357-2725(01)00070-x. [Article]
- Hyder A, Zenhom M, Klapper M, Herrmann J, Schrezenmeir J: Expression of fatty acid binding proteins 3 and 5 genes in rat pancreatic islets and INS-1E cells: regulation by fatty acids and glucose. Islets. 2010 May-Jun;2(3):174-84. doi: 10.4161/isl.2.3.11454. [Article]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Oleic acid binding
- Specific Function
- FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters.
- Gene Name
- FABP3
- Uniprot ID
- P05413
- Uniprot Name
- Fatty acid-binding protein, heart
- Molecular Weight
- 14857.93 Da
References
- Zanotti G, Scapin G, Spadon P, Veerkamp JH, Sacchettini JC: Three-dimensional structure of recombinant human muscle fatty acid-binding protein. J Biol Chem. 1992 Sep 15;267(26):18541-50. [Article]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Transporter activity
- Specific Function
- FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. FABP2 is probably involved in triglyceride-rich lipoprotein synthesis. Binds satu...
- Gene Name
- FABP2
- Uniprot ID
- P12104
- Uniprot Name
- Fatty acid-binding protein, intestinal
- Molecular Weight
- 15207.165 Da
References
- Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [Article]
Drug created at June 13, 2005 13:24 / Updated at November 21, 2021 16:25