Protein phosphatase 3 catalytic subunit alpha

BE0004238ProteinHumansPPP3CA

Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals (PubMed:15671020, PubMed:18838687, PubMed:19154138, PubMed:23468591, PubMed:30254215). It is acted on by 9 drugs in DrugBank.

Gene name
PPP3CA
UniProtKB entry
Q08209Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
521 residues · 58,687 Da
Also known as
3.1.3.16 · Calcineurin A alpha · Calmodulin-dependent calcineurin A subunit alpha isoform · CALNA · CAM-PRP catalytic subunit

Resolves to

Protein
UniProtQ08209UniProt namePP2BA_HUMAN
Gene
HGNCHGNC:9314NCBI Gene5530GenBank306477GeneCardsPPP3CA
Pharmacology
KEGGhsa:5530
Structure
PDB1AUIPDB1M63PDB1MF8
Drugs

What you can answer from here — as of September 03, 2024

9DrugsApproved to experimental, with action, bond type and pharmacological action
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19GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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32+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Protein phosphatase 3 catalytic subunit alpha, how selective are they, and which programs against it are still in active trials?

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