Tropisetron is a 5HT-3 receptor antagonist used as an antiemetic in the treatment of chemotherapy-induced nausea and vomiting. Tropisetron is an indole derivative with antiemetic activity.
- Mechanism
- Curator reviewed
Tropisetron competitively binds to and blocks the action of serotonin at 5HT3 receptors peripherally on vagus nerve terminals located in the gastrointestinal (GI) tract as well as centrally in the chemoreceptor trigger zone (CTZ) of the area postrema of the central nervous system (CNS). This results in the suppression of chemotherapy- and radiotherapy-induced nausea and vomiting.
- Primary indication
- For the prevention of nausea and vomiting induced by cytotoxic therapy and postoperative.Curator reviewed · 2 structured indications
- Formula / weight
- C17H20N2O2 · 284.3529 g/mol (avg)
Resolves to
ZNRGQMMCGHDTEI-ITGUQSILSA-NSMILES[H][C@]12CC[C@]([H])(C[C@@]([H])(C1)OC(=O)C1=CNC3=CC=CC=C13)N2CWhat you can answer from here — as of September 23, 2026
Which drugs share a target with Tropisetron, and which of those have an active Phase 3 trial?
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