ADP-ribosylation factor 6

BE0004242ProteinHumansARF6

GTP-binding protein involved in protein trafficking that regulates endocytic recycling and cytoskeleton remodeling (PubMed:11266366, PubMed:16737952, PubMed:18400762, PubMed:21170023, PubMed:32103017, PubMed:7589240). It is acted on by 3 drugs in DrugBank.

Gene name
ARF6
UniProtKB entry
P62330Swiss-Prot
Cellular location
Cytoplasm, cytosol
Residues / weight
175 residues · 20,082 Da
Also known as
3.6.5.2

Resolves to

Protein
UniProtP62330UniProt nameARF6_HUMAN
Gene
HGNCHGNC:659NCBI Gene382GenBank178989GeneCardsARF6
Pharmacology
IUPHAR/GtoPdb3324KEGGhsa:382
Structure
PDB1E0SPDB2A5DPDB2A5F
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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27GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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39+ReferencesStructured and connected to the statements they support
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Which compounds in development act on ADP-ribosylation factor 6, and which indications are they being tested in?

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