Actin-related protein 2/3 complex subunit 4

BE0004254ProteinHumansARPC4

Actin-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9230079). It is acted on by 2 drugs in DrugBank.

Gene name
ARPC4
UniProtKB entry
P59998Swiss-Prot
Cellular location
Cytoplasm, cytoskeleton
Residues / weight
168 residues · 19,667 Da
Also known as
ARC20 · Arp2/3 complex 20 kDa subunit · p20-ARC

Resolves to

Protein
UniProtP59998UniProt nameARPC4_HUMAN
Gene
HGNCHGNC:707NCBI Gene10093GenBank2444287GeneCardsARPC4
Pharmacology
KEGGhsa:10093
Structure
PDB6UHCPDB6YW6PDB6YW7
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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3GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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8+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Actin-related protein 2/3 complex subunit 4, and which indications are they being tested in?

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