Cholix toxin

BE0004282ProteinVibrio choleraechxA

An NAD-dependent ADP-ribosyltransferase (ADPRT), it catalyzes the transfer of the ADP-ribosyl moiety of oxidized NAD onto eukaryotic elongation factor 2 (eEF-2) thus arresting protein synthesis. It is acted on by 1 drug in DrugBank.

Gene name
chxA
UniProtKB entry
Q5EK40Swiss-Prot
Residues / weight
666 residues · 74,293 Da
Also known as
2.4.2.36 · Exotoxin A · NAD(+)--diphthamide ADP-ribosyltransferase · toxA

Resolves to

Protein
UniProtQ5EK40UniProt nameCHXA_VIBCL
Gene
GenBank58615287
Structure
PDB2Q5TPDB2Q6MPDB3ESS
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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1GO termFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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5+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Cholix toxin, and which indications are they being tested in?

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