Tyrosine-protein kinase Lyn

BE0004315ProteinHumansLYN

Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors and plays an important role in the regulation of innate and adaptive immune responses, hematopoiesis, responses to growth factors and cytokines, integrin signaling, but also... It is acted on by 10 drugs in DrugBank.

Gene name
LYN
UniProtKB entry
P07948Swiss-Prot
Cellular location
Cell membrane
Residues / weight
512 residues · 58,574 Da
Also known as
2.7.10.2 · JTK8 · Lck/Yes-related novel protein tyrosine kinase · p53Lyn · p56Lyn

Resolves to

Protein
UniProtP07948UniProt nameLYN_HUMAN
Gene
HGNCHGNC:6735NCBI Gene4067GenBank307144GeneCardsLYN
Pharmacology
IUPHAR/GtoPdb2060KEGGhsa:4067
Structure
PDB1W1FPDB1WA7PDB3A4O
Drugs

What you can answer from here — as of September 07, 2019

10DrugsApproved to experimental, with action, bond type and pharmacological action
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5Clinical trialsTrials of drugs acting on it, by phase and status
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74GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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99+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Tyrosine-protein kinase Lyn, how selective are they, and which programs against it are still in active trials?

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