Type II restriction enzyme EcoRV

BE0004366ProteinEscherichia coliecoRVR

A P subtype restriction enzyme that recognizes the double-stranded sequence 5'-GATATC-3' and cleaves after T-3. It is acted on by 1 drug in DrugBank.

Gene name
ecoRVR
UniProtKB entry
P04390Swiss-Prot
Residues / weight
245 residues · 28,650 Da
Also known as
3.1.21.4 · Endonuclease EcoRV · R.EcoRV · Type-2 restriction enzyme EcoRV

Resolves to

Protein
UniProtP04390UniProt nameT2E5_ECOLX
Gene
NCBI Gene14401263GenBank41325
Pharmacology
KEGGpg:14401263
Structure
PDB1AZ0PDB1AZ3PDB1AZ4
Drugs

What you can answer from here — as of May 03, 2025

1DrugApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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9+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Type II restriction enzyme EcoRV, and which indications are they being tested in?

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