Small conductance calcium-activated potassium channel protein 2

BE0004426ProteinHumansKCNN2

Small conductance calcium-activated potassium channel that mediates the voltage-independent transmembrane transfer of potassium across the cell membrane through a constitutive interaction with calmodulin which binds the intracellular calcium allowing its opening (PubMed:10991935, PubMed:33242881, PubMed:9287325). It is acted on by 7 drugs in DrugBank.

Gene name
KCNN2
UniProtKB entry
Q9H2S1Swiss-Prot
Cellular location
Membrane
Residues / weight
579 residues · 63,759 Da
Also known as
KCa2.2 · SK2 · SKCa 2 · SKCa2

Resolves to

Protein
UniProtQ9H2S1UniProt nameKCNN2_HUMAN
Gene
HGNCHGNC:6291NCBI Gene3781GenBank10334701GeneCardsKCNN2
Pharmacology
IUPHAR/GtoPdb382KEGGhsa:3781
Structure
PDB5V02PDB5V03PDB5WBX
Drugs

What you can answer from here — as of September 07, 2019

7DrugsApproved to experimental, with action, bond type and pharmacological action
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3GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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14+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Small conductance calcium-activated potassium channel protein 2, how selective are they, and which programs against it are still in active trials?

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