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ZOXAZOLAMINE

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

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Identification

Generic Name
ZOXAZOLAMINE
DrugBank Accession Number
DB19372
Background

Not Available

Type
Small Molecule
Groups
Withdrawn
Structure
3D
Similar Structures
Weight
Average: 168.58
Monoisotopic: 168.0090405
Chemical Formula
C7H5ClN2O
Synonyms
  • 2-amino-5-chlorobenzoxazole
  • 5-chloro-2-benzoxazolamine
  • Contrazole
  • Deflexol
  • Flexin
  • Miazol
  • Uri-boi
  • Zoxamine
  • Zoxine
External IDs
  • MCN-485
  • NSC-24995
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Pharmacology

Indication

Not Available

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Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
TargetActionsOrganism
ASmall conductance calcium-activated potassium channel protein 2
activator
Humans
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Categories

Drug Categories
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
9DOW362Q29
CAS number
61-80-3
InChI Key
YGCODSQDUUUKIV-UHFFFAOYSA-N
InChI
InChI=1S/C7H5ClN2O/c8-4-1-2-6-5(3-4)10-7(9)11-6/h1-3H,(H2,9,10)
IUPAC Name
SMILES
NC1=NC2=CC(Cl)=CC=C2O1

References

General References
Not Available
Human Metabolome Database
HMDB0260050
KEGG Compound
C13841
BindingDB
50127011
ChEBI
35053
ChEMBL
CHEMBL472566
ZINC
ZINC000008614810
PDBe Ligand
36R
PDB Entries
4qp2

Clinical Trials

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Not AvailableWithdrawnTreatmentPain Relief1somestatusstop reasonjust information to hide

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available
Chromatographic Properties
Collision Cross Sections (CCS)
Not Available

Targets

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Details1. Small conductance calcium-activated potassium channel protein 2
Kind
Protein
Organism
Humans
Pharmacological action
Yes
Actions
Activator
General Function
Forms a voltage-independent potassium channel activated by intracellular calcium (PubMed:10991935, PubMed:33242881, PubMed:9287325). Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization
Specific Function
Alpha-actinin binding
Gene Name
KCNN2
Uniprot ID
Q9H2S1
Uniprot Name
Small conductance calcium-activated potassium channel protein 2
Molecular Weight
63759.03 Da
References
  1. Zhou Y, Zhang Y, Zhao D, Yu X, Shen X, Zhou Y, Wang S, Qiu Y, Chen Y, Zhu F: TTD: Therapeutic Target Database describing target druggability information. Nucleic Acids Res. 2024 Jan 5;52(D1):D1465-D1477. doi: 10.1093/nar/gkad751. [Article]

Drug created at August 26, 2024 17:01 / Updated at September 18, 2024 01:29