Eukaryotic peptide chain release factor GTP-binding subunit ERF3A

BE0004448ProteinHumansGSPT1

GTPase component of the eRF1-eRF3-GTP ternary complex, a ternary complex that mediates translation termination in response to the termination codons UAA, UAG and UGA (PubMed:15987998, PubMed:19417105, PubMed:2511002, PubMed:27863242). It is acted on by 3 drugs in DrugBank.

Gene name
GSPT1
UniProtKB entry
P15170Swiss-Prot
Residues / weight
499 residues · 55,756 Da
Also known as
3.6.5.- · ERF3A · Eukaryotic peptide chain release factor subunit 3a · G1 to S phase transition protein 1 homolog

Resolves to

Protein
UniProtP15170UniProt nameERF3A_HUMAN
Gene
HGNCHGNC:4621NCBI Gene2935GeneCardsGSPT1
Pharmacology
KEGGhsa:2935
Structure
PDB3E1YPDB3J5YPDB3KUI
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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11+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Eukaryotic peptide chain release factor GTP-binding subunit ERF3A, and which indications are they being tested in?

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