Citrate synthase, mitochondrial

BE0004459ProteinHumansCS

Key enzyme of the Krebs tricarboxylic acid cycle which catalyzes the synthesis of citrate from acetyl coenzyme A and oxaloacetate. It is acted on by 8 drugs in DrugBank.

Gene name
CS
UniProtKB entry
O75390Swiss-Prot
Cellular location
Mitochondrion matrix
Residues / weight
466 residues · 51,712 Da
Also known as
2.3.3.1 · Citrate (Si)-synthase

Resolves to

Protein
UniProtO75390UniProt nameCISY_HUMAN
Gene
HGNCHGNC:2422NCBI Gene1431GeneCardsCS
Pharmacology
KEGGhsa:1431
Structure
PDB5UZPPDB5UZQPDB5UZR
Drugs

What you can answer from here — as of September 07, 2019

8DrugsApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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20+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Citrate synthase, mitochondrial, how selective are they, and which programs against it are still in active trials?

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