Adenylate kinase 2, mitochondrial

BE0004477ProteinHumansAK2

Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. It is acted on by 6 drugs in DrugBank.

Gene name
AK2
UniProtKB entry
P54819Swiss-Prot
Cellular location
Mitochondrion intermembrane space
Residues / weight
239 residues · 26,477 Da
Also known as
2.7.4.3 · Adenylate monophosphate kinase · ADK2 · AK 2 · ATP-AMP transphosphorylase 2

Resolves to

Protein
UniProtP54819UniProt nameKAD2_HUMAN
Gene
HGNCHGNC:362NCBI Gene204GeneCardsAK2
Pharmacology
KEGGhsa:204
Structure
PDB2C9YPDB9FL7PDB9GR0
Drugs

What you can answer from here — as of September 07, 2019

6DrugsApproved to experimental, with action, bond type and pharmacological action
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4Metabolic reactionsDrug transformations it catalyses, substrate to product
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2GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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20+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Adenylate kinase 2, mitochondrial, how selective are they, and which programs against it are still in active trials?

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