Guanine nucleotide-binding protein G(i) subunit alpha-1

BE0004491ProteinHumansGNAI1

Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades (PubMed:18434541, PubMed:33762731, PubMed:34239069, PubMed:35610220, PubMed:37935376, PubMed:37935377, PubMed:37963465, PubMed:38552625, PubMed:8774883, PubMed:38918398, PubMed:40080544). It is acted on by 2 drugs in DrugBank.

Gene name
GNAI1
UniProtKB entry
P63096Swiss-Prot
Cellular location
Cell membrane
Residues / weight
354 residues · 40,361 Da
Also known as
3.6.5.- · Adenylate cyclase-inhibiting G alpha protein

Resolves to

Protein
UniProtP63096UniProt nameGNAI1_HUMAN
Gene
HGNCHGNC:4384NCBI Gene2770GeneCardsGNAI1
Pharmacology
KEGGhsa:2770
Structure
PDB1KJYPDB1Y3APDB20YC
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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30GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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20+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Guanine nucleotide-binding protein G(i) subunit alpha-1, and which indications are they being tested in?

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