Neurocan core protein

BE0004512ProteinHumansNCAN

May modulate neuronal adhesion and neurite growth during development by binding to neural cell adhesion molecules (NG-CAM and N-CAM). It is acted on by 3 drugs in DrugBank.

Gene name
NCAN
UniProtKB entry
O14594Swiss-Prot
Cellular location
Secreted
Residues / weight
1,321 residues · 143,092 Da
Also known as
Chondroitin sulfate proteoglycan 3 · CSPG3 · NEUR

Resolves to

Protein
UniProtO14594UniProt nameNCAN_HUMAN
Gene
HGNCHGNC:2465NCBI Gene1463GeneCardsNCAN
Pharmacology
KEGGhsa:1463
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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3GO termsFunction, process and component, as structured annotations
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5Pfam domainsDomain architecture mapped to Pfam families and clans
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7+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Neurocan core protein, how selective are they, and which programs against it are still in active trials?

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