Elongation factor Tu, mitochondrial

BE0004542ProteinHumansTUFM

GTP hydrolase that promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. It is acted on by 5 drugs in DrugBank.

Gene name
TUFM
UniProtKB entry
P49411Swiss-Prot
Cellular location
Mitochondrion matrix
Residues / weight
455 residues · 49,875 Da
Also known as
3.6.5.3 · EF-Tu · P43

Resolves to

Protein
UniProtP49411UniProt nameEFTU_HUMAN
Gene
HGNCHGNC:12420NCBI Gene7284GeneCardsTUFM
Pharmacology
KEGGhsa:7284
Structure
PDB7A5GPDB7O9K
Drugs

What you can answer from here — as of September 07, 2019

5DrugsApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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16+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Elongation factor Tu, mitochondrial, how selective are they, and which programs against it are still in active trials?

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