Nuclear receptor ROR-alpha

BE0004545ProteinHumansRORA

Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. It is acted on by 3 drugs in DrugBank.

Gene name
RORA
UniProtKB entry
P35398Swiss-Prot
Cellular location
Nucleus
Residues / weight
523 residues · 58,974 Da
Also known as
NR1F1 · Nuclear receptor RZR-alpha · Nuclear receptor subfamily 1 group F member 1 · RAR-related orphan receptor A · Retinoid-related orphan receptor-alpha

Resolves to

Protein
UniProtP35398UniProt nameRORA_HUMAN
Gene
HGNCHGNC:10258NCBI Gene6095GeneCardsRORA
Pharmacology
IUPHAR/GtoPdb598KEGGhsa:6095
Structure
PDB1N83PDB1S0XPDB4S15
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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15GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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33+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Nuclear receptor ROR-alpha, how selective are they, and which programs against it are still in active trials?

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