Histone acetyltransferase KAT5

BE0004578ProteinHumansKAT5

Catalytic subunit of the NuA4 histone acetyltransferase complex, a multiprotein complex involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H2A and H4 (PubMed:12776177, PubMed:14966270, PubMed:15042092, PubMed:15121871, PubMed:15310756, PubMed:16387653, PubMed:19909775, PubMed:25865756,... It is acted on by 3 drugs in DrugBank.

Gene name
KAT5
UniProtKB entry
Q92993Swiss-Prot
Cellular location
Nucleus
Residues / weight
513 residues · 58,581 Da
Also known as
2.3.1.48 · 60 kDa Tat-interactive protein · cPLA(2)-interacting protein · Histone acetyltransferase HTATIP · HIV-1 Tat interactive protein

Resolves to

Protein
UniProtQ92993UniProt nameKAT5_HUMAN
Gene
HGNCHGNC:5275NCBI Gene10524GeneCardsKAT5
Pharmacology
IUPHAR/GtoPdb2664KEGGhsa:10524
Structure
PDB2EKOPDB2OU2PDB4QQG
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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52GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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39+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Histone acetyltransferase KAT5, how selective are they, and which programs against it are still in active trials?

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