Sterol O-acyltransferase 2

BE0004608ProteinHumansSOAT2

Catalyzes the formation of fatty acid-cholesterol esters, which are less soluble in membranes than cholesterol (PubMed:11294643, PubMed:16647063). It is acted on by 5 drugs in DrugBank.

Gene name
SOAT2
UniProtKB entry
O75908Swiss-Prot
Cellular location
Endoplasmic reticulum membrane
Residues / weight
522 residues · 59,896 Da
Also known as
2.3.1.26 · ACACT2 · ACAT-2 · ACAT2 · Acyl-coenzyme A:cholesterol acyltransferase 2

Resolves to

Protein
UniProtO75908UniProt nameSOAT2_HUMAN
Gene
HGNCHGNC:11178NCBI Gene8435GeneCardsSOAT2
Pharmacology
KEGGhsa:8435
Structure
PDB7N6QPDB7N6R
Drugs

What you can answer from here — as of September 07, 2019

5DrugsApproved to experimental, with action, bond type and pharmacological action
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12GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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17+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Sterol O-acyltransferase 2, and which indications are they being tested in?

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