ADP-ribosylation factor-like protein 3

BE0004638ProteinHumansARL3

Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP) (PubMed:16525022, PubMed:18588884). It is acted on by 2 drugs in DrugBank.

Gene name
ARL3
UniProtKB entry
P36405Swiss-Prot
Cellular location
Golgi apparatus membrane
Residues / weight
182 residues · 20,455 Da
Also known as
ARFL3

Resolves to

Protein
UniProtP36405UniProt nameARL3_HUMAN
Gene
HGNCHGNC:694NCBI Gene403GeneCardsARL3
Pharmacology
KEGGhsa:403
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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11GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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19+ReferencesStructured and connected to the statements they support
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Which compounds in development act on ADP-ribosylation factor-like protein 3, and which indications are they being tested in?

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