ADP-ribosylation factor-like protein 3

Details

Name
ADP-ribosylation factor-like protein 3
Kind
protein
Synonyms
  • ARFL3
Gene Name
ARL3
UniProtKB Entry
P36405Swiss-Prot
Organism
Humans
NCBI Taxonomy ID
9606
Amino acid sequence
>lcl|BSEQ0013234|ADP-ribosylation factor-like protein 3
MGLLSILRKLKSAPDQEVRILLLGLDNAGKTTLLKQLASEDISHITPTQGFNIKSVQSQG
FKLNVWDIGGQRKIRPYWKNYFENTDILIYVIDSADRKRFEETGQELAELLEEEKLSCVP
VLIFANKQDLLTAAPASEIAEGLNLHTIRDRVWQIQSCSALTGEGVQDGMNWVCKNVNAK
KK
Number of residues
182
Molecular Weight
20455.335
Theoretical pI
Not Available
GO Classification
Functions
magnesium ion binding
Processes
cilium assembly / Golgi to plasma membrane transport / mitotic cytokinesis / protein localization to ciliary membrane / protein localization to cilium / small GTPase-mediated signal transduction
Components
cilium / cytoplasm / microtubule cytoskeleton / nucleoplasm
General Function
Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP) (PubMed:16525022, PubMed:18588884). Required for normal cytokinesis and cilia signaling (PubMed:22085962). Requires assistance from GTPase-activating proteins (GAPs) like RP2 and PDE6D, in order to cycle between inactive GDP-bound and active GTP-bound forms. Required for targeting proteins to the cilium, including myristoylated NPHP3 and prenylated INPP5E (PubMed:30269812). Targets NPHP3 to the ciliary membrane by releasing myristoylated NPHP3 from UNC119B cargo adapter into the cilium (PubMed:22085962). Required for PKD1:PKD2 complex targeting from the trans-Golgi network to the cilium (By similarity)
Specific Function
Gdp binding
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
Not Available
Cellular Location
Golgi apparatus membrane
Gene sequence
>lcl|BSEQ0013235|ADP-ribosylation factor-like protein 3 (ARL3)
ATGGGCTTGCTCTCAATTTTGCGCAAGTTGAAAAGTGCACCAGACCAGGAGGTGAGAATA
CTTCTCCTGGGCTTGGATAATGCTGGCAAGACCACTCTTCTGAAGCAGCTTGCATCTGAA
GACATCAGCCACATCACACCTACACAGGGTTTCAACATCAAAAGTGTACAATCACAAGGT
TTTAAACTGAATGTATGGGACATTGGTGGACAGAGGAAAATCAGACCATACTGGAAGAAT
TATTTTGAAAATACCGATATTCTTATATATGTAATCGACAGTGCAGACAGAAAAAGATTT
GAAGAGACGGGTCAGGAACTAGCGGAATTACTGGAGGAAGAAAAACTAAGTTGTGTGCCA
GTGCTCATCTTTGCTAATAAGCAGGATTTGCTCACAGCAGCCCCTGCCTCTGAAATTGCA
GAAGGACTGAACCTGCATACCATCCGCGACCGAGTCTGGCAGATCCAGTCTTGCTCAGCT
CTCACAGGAGAGGGCGTTCAGGATGGCATGAACTGGGTCTGCAAAAATGTCAATGCAAAG
AAGAAATAA
Chromosome Location
10
Locus
10q24.32
External Identifiers
ResourceLink
UniProtKB IDP36405
UniProtKB Entry NameARL3_HUMAN
GeneCard IDARL3
HGNC IDHGNC:694
KEGG IDhsa:403
NCBI Gene ID403
General References
  1. Cavenagh MM, Breiner M, Schurmann A, Rosenwald AG, Terui T, Zhang C, Randazzo PA, Adams M, Joost HG, Kahn RA: ADP-ribosylation factor (ARF)-like 3, a new member of the ARF family of GTP-binding proteins cloned from human and rat tissues. J Biol Chem. 1994 Jul 22;269(29):18937-42. [Article]
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  5. Bhamidipati A, Lewis SA, Cowan NJ: ADP ribosylation factor-like protein 2 (Arl2) regulates the interaction of tubulin-folding cofactor D with native tubulin. J Cell Biol. 2000 May 29;149(5):1087-96. [Article]
  6. Van Valkenburgh H, Shern JF, Sharer JD, Zhu X, Kahn RA: ADP-ribosylation factors (ARFs) and ARF-like 1 (ARL1) have both specific and shared effectors: characterizing ARL1-binding proteins. J Biol Chem. 2001 Jun 22;276(25):22826-37. Epub 2001 Apr 12. [Article]
  7. Grayson C, Bartolini F, Chapple JP, Willison KR, Bhamidipati A, Lewis SA, Luthert PJ, Hardcastle AJ, Cowan NJ, Cheetham ME: Localization in the human retina of the X-linked retinitis pigmentosa protein RP2, its homologue cofactor C and the RP2 interacting protein Arl3. Hum Mol Genet. 2002 Nov 15;11(24):3065-74. [Article]
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  9. Behnia R, Panic B, Whyte JR, Munro S: Targeting of the Arf-like GTPase Arl3p to the Golgi requires N-terminal acetylation and the membrane protein Sys1p. Nat Cell Biol. 2004 May;6(5):405-13. Epub 2004 Apr 11. [Article]
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Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
2-(N-morpholino)ethanesulfonic acidexperimentalunknowntargetDetails
Guanosine-5'-DiphosphateexperimentalunknowntargetDetails