Inhibitor of nuclear factor kappa-B kinase subunit alpha

BE0004655ProteinHumansCHUK

Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses (PubMed:18626576, PubMed:9244310, PubMed:9252186,... It is acted on by 8 drugs in DrugBank.

Gene name
CHUK
UniProtKB entry
O15111Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
745 residues · 84,639 Da
Also known as
2.7.11.10 · Conserved helix-loop-helix ubiquitous kinase · I-kappa-B kinase 1 · I-kappa-B kinase alpha · IkappaB kinase

Resolves to

Protein
UniProtO15111UniProt nameIKKA_HUMAN
Gene
HGNCHGNC:1974NCBI Gene1147GeneCardsCHUK
Pharmacology
IUPHAR/GtoPdb1989KEGGhsa:1147
Structure
PDB3BRTPDB5EBZPDB5TQW
Drugs

What you can answer from here — as of September 07, 2019

8DrugsApproved to experimental, with action, bond type and pharmacological action
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12GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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48+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Inhibitor of nuclear factor kappa-B kinase subunit alpha, how selective are they, and which programs against it are still in active trials?

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