Protein smoothened

BE0004659ProteinHumansSMO

G protein-coupled receptor, which transduces the smoothened signaling pathway (PubMed:19592253, PubMed:27437577, PubMed:28344083, PubMed:31168089, PubMed:32929279, PubMed:36202993). It is acted on by 10 drugs in DrugBank.

Gene name
SMO
UniProtKB entry
Q99835Swiss-Prot
Cellular location
Cell membrane
Residues / weight
787 residues · 86,396 Da
Also known as
Protein Gx · SMOH

Resolves to

Protein
UniProtQ99835UniProt nameSMO_HUMAN
Gene
HGNCHGNC:11119NCBI Gene6608GeneCardsSMO
Pharmacology
IUPHAR/GtoPdb239KEGGhsa:6608
Structure
PDB4JKVPDB4N4WPDB4O9R
Drugs

What you can answer from here — as of September 03, 2024

10DrugsApproved to experimental, with action, bond type and pharmacological action
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11Clinical trialsTrials of drugs acting on it, by phase and status
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20GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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36+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Protein smoothened, how selective are they, and which programs against it are still in active trials?

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