Halcinonide

DB06786ApprovedWithdrawnSmall moleculeCorticosteroids

Halcinonide is a corticosteroid used for the management and symptomatic relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. Halcinonide is marketed under the brand name Halog® by Ranbaxy Laboratories Inc.

Mechanism: The precise mechanism of action of topical corticosteroids is unclear. However they possess anti-inflammatory, antipruritic, and vasoconstrictive actions.
New research indicates that halcinonide activates MBP (myelin basic protein) expression via smoothened receptor activation. This finding suggests that halcinonide could be used in the treatment of multiple sclerosis therapy as an alternative to Dexamethasone or Methylprednisolone.
Curator reviewed
Primary indication: Indicated for the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses.Curator reviewed · 3 structured indications
Formula / weight: C₂₄H₃₂ClFO₅ · 454.96 g/mol (avg)
First approval: Canada, 2005 · United States, 2008
Code names: SQ-18566
Brand names: Halog

Resolves to

Compound

UNIISI86V6QNEGCAS3093-35-4ChEMBLCHEMBL1200845ChEBI31663PubChem443943KEGGD01308

Clinical / RWD

RxNorm5084ATCD07AD02

Structure

InChIKeyMUQNGPZZQDCDFT-JNQJZLCISA-NSMILES[H][C@@]12C[C@H]3OC(C)(C)O[C@@]3(C(=O)CCl)[C@@]1(C)C[C@H](O)[C@@]1(F)[C@@]2([H])CCC2=CC(=O)CC[C@]12C

Targets

P04150NR3C1Q99835SMOP62508ESRRGO95718ESRRBP11474ESRRA

What you can answer from here — as of September 23, 2026

5Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

161Drug interactionsStructured to mechanism, not free text

3Structured indicationsCondition, population, route and combination as fields, not prose

21Marketed productsAcross 3 countries and 11 labellers

1ATC codeIncluding every combination product, plus 16 drug categories

11+ReferencesStructured and connected to the statements they support

Which drugs share a target with Halcinonide, and which of those have an active Phase 3 trial?

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