Myc proto-oncogene protein

BE0004689ProteinHumansMYC

Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3' (PubMed:24940000, PubMed:25956029). It is acted on by 5 drugs in DrugBank.

Gene name
MYC
UniProtKB entry
P01106Swiss-Prot
Cellular location
Nucleus, nucleoplasm
Residues / weight
454 residues · 50,565 Da
Also known as
BHLHE39 · Class E basic helix-loop-helix protein 39 · Proto-oncogene c-Myc · Transcription factor p64

Resolves to

Protein
UniProtP01106UniProt nameMYC_HUMAN
Gene
HGNCHGNC:7553NCBI Gene4609GeneCardsMYC
Pharmacology
KEGGhsa:4609
Structure
PDB1A93PDB1EE4PDB1MV0
Drugs

What you can answer from here — as of September 07, 2019

5DrugsApproved to experimental, with action, bond type and pharmacological action
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38Clinical trialsTrials of drugs acting on it, by phase and status
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40GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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48+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Myc proto-oncogene protein, how selective are they, and which programs against it are still in active trials?

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