Urea transporter 2

BE0004691ProteinHumansSLC14A2

Mediates the transport of urea driven by a concentration gradient across the cell membrane of the renal inner medullary collecting duct which is critical to the urinary concentrating mechanism. It is acted on by 2 drugs in DrugBank.

Gene name
SLC14A2
UniProtKB entry
Q15849Swiss-Prot
Cellular location
Apical cell membrane
Residues / weight
920 residues · 101,208 Da
Also known as
HUT2 · Solute carrier family 14 member 2 · Urea transporter, kidney · UT2

Resolves to

Protein
UniProtQ15849UniProt nameUT2_HUMAN
Gene
HGNCHGNC:10919NCBI Gene8170GeneCardsSLC14A2
Pharmacology
IUPHAR/GtoPdb983KEGGhsa:8170
Structure
PDB8BLOPDB8XD7PDB8XD9
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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7GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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8+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Urea transporter 2, how selective are they, and which programs against it are still in active trials?

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