Urea transporter 1

BE0004692ProteinHumansSLC14A1

Mediates the transport of urea driven by a concentration gradient across the cell membrane of erythrocytes (PubMed:10514515, PubMed:7797558, PubMed:7989337, PubMed:8997401). It is acted on by 2 drugs in DrugBank.

Gene name
SLC14A1
UniProtKB entry
Q13336Swiss-Prot
Cellular location
Cell membrane
Residues / weight
389 residues · 42,528 Da
Also known as
HUT11 · JK · RACH1 · Solute carrier family 14 member 1 · Urea transporter, erythrocyte

Resolves to

Protein
UniProtQ13336UniProt nameUT1_HUMAN
Gene
HGNCHGNC:10918NCBI Gene6563GeneCardsSLC14A1
Pharmacology
IUPHAR/GtoPdb982KEGGhsa:6563
Structure
PDB6QD5PDB8BLPPDB8XDF
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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14+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Urea transporter 1, how selective are they, and which programs against it are still in active trials?

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