UDP-glucuronosyltransferase 1A7

BE0004695ProteinHumansUGT1A7

UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:12181437, PubMed:15470161, PubMed:18004212,... It is acted on by 13 drugs in DrugBank.

Gene name
UGT1A7
UniProtKB entry
Q9HAW7Swiss-Prot
Cellular location
Endoplasmic reticulum membrane
Residues / weight
530 residues · 59,818 Da
Also known as
2.4.1.17 · GNT1 · UDP-glucuronosyltransferase 1-7 · UDP-glucuronosyltransferase 1-G · UDPGT 1-7

Resolves to

Protein
UniProtQ9HAW7UniProt nameUD17_HUMAN
Gene
HGNCHGNC:12539NCBI Gene54577GeneCardsUGT1A7
Pharmacology
KEGGhsa:54577
Drugs

What you can answer from here — as of September 03, 2024

13DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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6Metabolic reactionsDrug transformations it catalyses, substrate to product
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5GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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26+ReferencesStructured and connected to the statements they support
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Which approved drugs act on UDP-glucuronosyltransferase 1A7, how selective are they, and which programs against it are still in active trials?

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