Sodium/nucleoside cotransporter 1

BE0004705ProteinHumansSLC28A1

Sodium and pyrimidine nucleoside symporter of the plasma membrane that imports uridine, thymidine and cytidine into cells by coupling their transport to the transmembrane sodium electrochemical gradient. It is acted on by 7 drugs in DrugBank.

Gene name
SLC28A1
UniProtKB entry
O00337Swiss-Prot
Cellular location
Cell membrane
Residues / weight
649 residues · 71,583 Da
Also known as
CNT 1 · CNT1 · Concentrative nucleoside transporter 1 · hCNT1 · Na(+)/nucleoside cotransporter 1

Resolves to

Protein
UniProtO00337UniProt nameS28A1_HUMAN
Gene
HGNCHGNC:11001NCBI Gene9154GeneCardsSLC28A1
Pharmacology
KEGGhsa:9154
Drugs

What you can answer from here — as of September 07, 2019

7DrugsApproved to experimental, with action, bond type and pharmacological action
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2Clinical trialsTrials of drugs acting on it, by phase and status
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13GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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15+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Sodium/nucleoside cotransporter 1, how selective are they, and which programs against it are still in active trials?

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