Stavudine

DB00649ApprovedInvestigationalSmall moleculeHuman Immunodeficiency Virus Nucleoside Analog Reverse Transcriptase InhibitorNucleoside and Nucleotide Reverse Transcriptase Inhibitors

Stavudine is a dideoxynucleoside used in the treatment of HIV infection. A dideoxynucleoside analog that inhibits reverse transcriptase and has in vitro activity against HIV.

Chemical structure of Stavudine
Mechanism
Curator reviewed
Primary indication
For the treatment of human immunovirus (HIV) infections.Curator reviewed · 1 structured indication
Formula / weight
C10H12N2O4 · 224.2133 g/mol (avg)
First approval
Canada, 1997 · United States, 1994
Also known as
Sanilvudine
Code names
BMY-27857 · d4T · NSC-163661
Brand names
  • Zerit

Resolves to

Compound
UNIIBO9LE4QFZFCAS3056-17-5ChEMBLCHEMBL991ChEBI63581PubChem18283KEGGD00445
Clinical / RWD
RxNorm59763ATCJ05AF04ATCJ05AR07ATCJ05AR28PharmGKBPA451494
Structure
InChIKeyXNKLLVCARDGLGL-JGVFFNPUSA-NSMILESCC1=CN([C@@H]2O[C@H](CO)C=C2)C(=O)NC1=O
Targets
Q72547polP03366gag-pol
Transporters
Q4U2R8SLC22A6O00337SLC28A1

What you can answer from here — as of September 29, 2026

2Protein targetsEach mapped to UniProt, with action and pharmacological action
Listed above
2TransportersSubstrate / inhibitor direction, not just membership
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776Drug interactionsStructured to mechanism, not free text
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38Clinical trialsPhase, status and sponsor resolved per trial
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1Structured indicationCondition, population, route and combination as fields, not prose
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110Marketed productsAcross 8 countries and 30 labellers
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3ATC codesIncluding every combination product, plus 28 drug categories
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8+ReferencesStructured and connected to the statements they support
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