Reduced folate transporter

BE0004711ProteinHumansSLC19A1

Antiporter that mediates the import of reduced folates or a subset of cyclic dinucleotides, driven by the export of organic anions (PubMed:10787414, PubMed:15337749, PubMed:16115875, PubMed:22554803, PubMed:31126740, PubMed:31511694, PubMed:32276275, PubMed:36071163, PubMed:36265513, PubMed:36575193, PubMed:7826387, PubMed:9041240). It is acted on by 8 drugs in DrugBank.

Gene name
SLC19A1
UniProtKB entry
P41440Swiss-Prot
Cellular location
Cell membrane
Residues / weight
591 residues · 64,868 Da
Also known as
Cyclic dinucleotide:anion antiporter SLC19A1 · FLOT1 · Folate:anion antiporter SLC19A1 · FOLT · hRFC

Resolves to

Protein
UniProtP41440UniProt nameS19A1_HUMAN
Gene
HGNCHGNC:10937NCBI Gene6573GeneCardsSLC19A1
Pharmacology
IUPHAR/GtoPdb1014KEGGhsa:6573
Structure
PDB7TX6PDB7TX7PDB7XPZ
Drugs

What you can answer from here — as of September 03, 2024

8DrugsApproved to experimental, with action, bond type and pharmacological action
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2Clinical trialsTrials of drugs acting on it, by phase and status
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17GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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31+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Reduced folate transporter, how selective are they, and which programs against it are still in active trials?

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