Levomefolic acid is a folate supplement used to prevent neural tube defects in pregnancy or folate deficiency. Levomefolic acid (INN) is the metabolite of folic acid (Vitamin B9) and it is a predominant active form of folate found in foods and in the blood circulation, accounting for 98% of folates in human...
- Mechanism
- Curator reviewed · 2 references
Levomefolic acid plays a critical role in methylating homocysteines into methionine by acting as a methyl donor in a reaction catalyzed by vitamine B12-dependent methionine synthase. Homocysteine must either be further metabolized via transulfuration to become cysteine, taurine, and glutathione via a B6-dependent process, or re-methylated to become methionine again. Methionine formed from remethylation of homocysteine by levomefolic acid forms the downstream metabolite S-adenosylmethionine (SAMe), which is involved in numerous biochemical methyl donation reactions, including reactions forming monoamine neurotransmitters. Studies suggest that high plasma levels of homocysteine is associated with increased incidences of arterial plaque formation.
- Primary indication
- For the treatment and prevention of folate deficiency and for use as an antidote against folic acid antagonists.Curator reviewed · 1 structured indication
- Formula / weight
- C20H25N7O6 · 459.4558 g/mol (avg)
- First approval
- Canada, 2012 · United States, 2010
- Also known as
- L-Methyl Folate · L-methylfolate · Levomefolate · LMSR
- Brand names
Resolves to
ZNOVTXRBGFNYRX-STQMWFEESA-NSMILESCN1[C@@H](CNC2=CC=C(C=C2)C(=O)N[C@@H](CCC(O)=O)C(O)=O)CNC2=C1C(=O)N=C(N)N2What you can answer from here — as of September 12, 2026
Which drugs share a target with Levomefolic acid, and which of those have an active Phase 3 trial?
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