Cytochrome P450 4F2

BE0004727ProteinHumansCYP4F2

A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, eicosanoids and vitamins (PubMed:10660572, PubMed:10833273, PubMed:11997390, PubMed:17341693, PubMed:18574070, PubMed:18577768). It is acted on by 12 drugs in DrugBank.

Gene name
CYP4F2
UniProtKB entry
P78329Swiss-Prot
Cellular location
Microsome membrane
Residues / weight
520 residues · 59,853 Da
Also known as
1.14.14.1 · 20-HETE synthase · 20-hydroxyeicosatetraenoic acid synthase · Arachidonic acid omega-hydroxylase · CYPIVF2

Resolves to

Protein
UniProtP78329UniProt nameCP4F2_HUMAN
Gene
HGNCHGNC:2645NCBI Gene8529GeneCardsCYP4F2
Pharmacology
IUPHAR/GtoPdb1344KEGGhsa:8529
Drugs

What you can answer from here — as of September 03, 2024

12DrugsApproved to experimental, with action, bond type and pharmacological action
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10Metabolic reactionsDrug transformations it catalyses, substrate to product
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10GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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37+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Cytochrome P450 4F2, how selective are they, and which programs against it are still in active trials?

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