Protein-tyrosine kinase 6

BE0004731ProteinHumansPTK6

Non-receptor tyrosine-protein kinase implicated in the regulation of a variety of signaling pathways that control the differentiation and maintenance of normal epithelia, as well as tumor growth. It is acted on by 4 drugs in DrugBank.

Gene name
PTK6
UniProtKB entry
Q13882Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
451 residues · 51,834 Da
Also known as
2.7.10.2 · Breast tumor kinase · BRK · Tyrosine-protein kinase BRK

Resolves to

Protein
UniProtQ13882UniProt namePTK6_HUMAN
Gene
HGNCHGNC:9617NCBI Gene5753GeneCardsPTK6
Pharmacology
IUPHAR/GtoPdb2182KEGGhsa:5753
Structure
PDB1RJAPDB2KGTPDB5D7V
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
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15GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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40+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Protein-tyrosine kinase 6, how selective are they, and which programs against it are still in active trials?

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