Tyrosine-protein kinase FRK

BE0004742ProteinHumansFRK

Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. It is acted on by 4 drugs in DrugBank.

Gene name
FRK
UniProtKB entry
P42685Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
505 residues · 58,254 Da
Also known as
2.7.10.2 · FYN-related kinase · Nuclear tyrosine protein kinase RAK · Protein-tyrosine kinase 5 · PTK5

Resolves to

Protein
UniProtP42685UniProt nameFRK_HUMAN
Gene
HGNCHGNC:3955NCBI Gene2444GeneCardsFRK
Pharmacology
IUPHAR/GtoPdb2025KEGGhsa:2444
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
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11GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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20+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Tyrosine-protein kinase FRK, how selective are they, and which programs against it are still in active trials?

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