LIM domain kinase 1

BE0004759ProteinHumansLIMK1

Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics. It is acted on by 4 drugs in DrugBank.

Gene name
LIMK1
UniProtKB entry
P53667Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
647 residues · 72,584 Da
Also known as
2.7.11.1 · LIMK · LIMK-1

Resolves to

Protein
UniProtP53667UniProt nameLIMK1_HUMAN
Gene
HGNCHGNC:6613NCBI Gene3984GeneCardsLIMK1
Pharmacology
IUPHAR/GtoPdb2054KEGGhsa:3984
Structure
PDB3S95PDB5HVJPDB5HVK
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
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7GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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34+ReferencesStructured and connected to the statements they support
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Which approved drugs act on LIM domain kinase 1, how selective are they, and which programs against it are still in active trials?

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