Sodium- and chloride-dependent betaine transporter

BE0004777ProteinHumansSLC6A12

Transporter that mediates cellular uptake of betaine and GABA in a sodium- and chloride-dependent process (PubMed:7589472). It is acted on by 2 drugs in DrugBank.

Gene name
SLC6A12
UniProtKB entry
P48065Swiss-Prot
Cellular location
Basolateral cell membrane
Residues / weight
614 residues · 69,368 Da
Also known as
BGT-1 · BGT1 · Na(+)/Cl(-) betaine/GABA transporter · Solute carrier family 6 member 12

Resolves to

Protein
UniProtP48065UniProt nameS6A12_HUMAN
Gene
HGNCHGNC:11045NCBI Gene6539GeneCardsSLC6A12
Pharmacology
IUPHAR/GtoPdb932KEGGhsa:6539
Structure
PDB9LNMPDB9LNNPDB9LNO
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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10GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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9+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Sodium- and chloride-dependent betaine transporter, how selective are they, and which programs against it are still in active trials?

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